Transcription regulation by biomolecular condensates
Biomolecular condensates regulate transcription by dynamically compartmentalizing the
transcription machinery. Classic models of transcription regulation focus on the recruitment …
transcription machinery. Classic models of transcription regulation focus on the recruitment …
New insights into YAP/TAZ-TEAD-mediated gene regulation and biological processes in cancer
Simple Summary The Hippo pathway is crucial for regulating cell growth, organ size, and
tissue regeneration. When this pathway goes awry, it can lead to uncontrolled cell growth …
tissue regeneration. When this pathway goes awry, it can lead to uncontrolled cell growth …
Prion-like domain mediated phase separation of ARID1A promotes oncogenic potential of Ewing's sarcoma
YR Kim, J Joo, HJ Lee, C Kim, JC Park, YS Yu… - Nature …, 2024 - nature.com
Liquid-liquid phase separation (LLPS) facilitates the formation of membraneless organelles
within cells, with implications in various biological processes and disease states. AT-rich …
within cells, with implications in various biological processes and disease states. AT-rich …
The Hippo pathway: organ size control and beyond
The Hippo signaling pathway is a highly conserved signaling network for controlling organ
size, tissue homeostasis, and regeneration. It integrates a wide range of intracellular and …
size, tissue homeostasis, and regeneration. It integrates a wide range of intracellular and …
CBX4 deletion promotes tumorigenesis under KrasG12D background by inducing genomic instability
F Chen, W Hou, X Yu, J Wu, Z Li, J Xu, Z Deng… - … and Targeted Therapy, 2023 - nature.com
Abstract Chromobox protein homolog 4 (CBX4) is a component of the Polycomb group
(PcG) multiprotein Polycomb repressive complexes 1 (PRC1), which is participated in …
(PcG) multiprotein Polycomb repressive complexes 1 (PRC1), which is participated in …
Phase separation of PML/RARα and BRD4 coassembled microspeckles governs transcriptional dysregulation in acute promyelocytic leukemia
Y Zhang, J Lou, Y Liu, P **, Y Tan, H Song… - Proceedings of the …, 2024 - pnas.org
In acute promyelocytic leukemia (APL), the promyelocytic leukemia-retinoic acid receptor
alpha (PML/RARα) fusion protein destroys PML nuclear bodies (NBs), leading to the …
alpha (PML/RARα) fusion protein destroys PML nuclear bodies (NBs), leading to the …
Liquid–liquid phase separation in diseases
X Zhang, L Yuan, W Zhang, Y Zhang, Q Wu, C Li… - MedComm, 2024 - Wiley Online Library
Liquid–liquid phase separation (LLPS), an emerging biophysical phenomenon, can
sequester molecules to implement physiological and pathological functions. LLPS …
sequester molecules to implement physiological and pathological functions. LLPS …
Onco-condensates: formation, multi-component organization, and biological functions
Numerous cellular processes occur in the context of condensates, a type of large,
membrane-less biomolecular assembly generated through phase separation. These …
membrane-less biomolecular assembly generated through phase separation. These …
Biomolecular condensates and disease pathogenesis
Biomolecular condensates or membraneless organelles (MLOs) formed by liquid-liquid
phase separation (LLPS) divide intracellular spaces into discrete compartments for specific …
phase separation (LLPS) divide intracellular spaces into discrete compartments for specific …
Small-molecule-induced epigenetic rejuvenation promotes SREBP condensation and overcomes barriers to CNS myelin regeneration
Remyelination failure in diseases like multiple sclerosis (MS) was thought to involve
suppressed maturation of oligodendrocyte precursors; however, oligodendrocytes are …
suppressed maturation of oligodendrocyte precursors; however, oligodendrocytes are …