From a clinical, morphological and molecular perspective, prostate cancer is a
heterogeneous disease. Primary prostate cancers are often multifocal, having …

Simple Summary In this review paper, we explore the role of chronic inflammation in the
pathogenesis of prostatic diseases, such as chronic prostatitis, benign prostatic hyperplasia …

Chronic inflammation and an immunosuppressive microenvironment promote prostate
cancer (PCa) progression and diminish the response to immune checkpoint blockade (ICB) …

Apoptosis deficiency is one of the most important features observed in neoplastic diseases.
The Bcl-2 family is composed of a subset of proteins that act as decisive apoptosis …

Background Castration-resistant prostate cancer (CRPC) occurs when prostate cancer
(CaP) progresses under therapy-induced castrate conditions. Several mechanisms have …

Rationale: Current therapies for metastatic osseous disease frequently fail to provide a
durable treatment response. To date, there are only limited therapeutic options for metastatic …

Prostate cancer (PCa) is a common and fatal type of cancer in men. Metastatic PCa (mPCa)
is a major factor contributing to its lethality, although the mechanisms remain poorly …

Prostate cancer is the most frequent nonskin cancer and second most common cause of
cancer-related deaths in man. Prostate cancer is a clinically heterogeneous disease with …

The role of dysregulation of mRNA alternative splicing (AS) in the development and
progression of solid tumors remains to be defined. Here we describe the first comprehensive …

Prostate cancer (PCa) is a prevalent malignancy that occurs primarily in old males. Prostate
tumors in different patients manifest significant inter-patient heterogeneity with respect to …