SUMMARY Extraintestinal pathogenic Escherichia coli (ExPEC) strains are responsible for a
majority of human extraintestinal infections globally, resulting in enormous direct medical …

Polymyxins are important lipopeptide antibiotics that serve as the last-line defense against
multidrug-resistant (MDR) Gram-negative bacterial infections. Worryingly, the clinical utility …

The emergence of microbial antibiotic resistance is a global health threat. In clinical settings,
the key to controlling spread of resistant strains is accurate and rapid detection. As …

The emergence and spread of mobile colistin (COL) resistance (mcr) genes jeopardize the
efficacy of COL, a last resort antibiotic for treating deadly infections. COL has been used in …

Colistin drug resistance is an emerging public health threat worldwide. The adaptability,
existence and spread of colistin drug resistance in multiple reservoirs and ecological …

Surface water receives large quantities of wastes from human and animal sources, thus
providing an ideal setting for the accumulation, development, and dissemination of antibiotic …

Antimicrobial resistance (AMR) is a global public-health emergency, which threatens the
advances made by modern medical care over the past century. The World Health …

Background Mobile colistin resistance (mcr) genes modify Lipid A molecules of the
lipopolysaccharide, changing the overall charge of the outer membrane. Results and …

Multi-drug resistant (MDR) E. coli constitute a major public health burden globally, reaching
the highest prevalence in the global south yet frequently flowing with travellers to other …

Carbapenem-resistant Enterobacteriaceae infections have spread globally, leaving
polymyxins, including colistin, as 'last-resort treatments'. Emerging colistin resistance raises …