Prefrontal cortex and depression

DA Pizzagalli, AC Roberts - Neuropsychopharmacology, 2022‏ - nature.com
The prefrontal cortex (PFC) has emerged as one of the regions most consistently impaired in
major depressive disorder (MDD). Although functional and structural PFC abnormalities …

Resting-state fMRI functional connectivity and mindfulness in clinical and non-clinical contexts: A review and synthesis

I Sezer, DA Pizzagalli, MD Sacchet - Neuroscience & Biobehavioral …, 2022‏ - Elsevier
This review synthesizes relations between mindfulness and resting-state fMRI functional
connectivity of brain networks. Mindfulness is characterized by present-moment awareness …

Altered connectivity in depression: GABA and glutamate neurotransmitter deficits and reversal by novel treatments

RS Duman, G Sanacora, JH Krystal - Neuron, 2019‏ - cell.com
The mechanisms underlying the pathophysiology and treatment of depression and stress-
related disorders remain unclear, but studies in depressed patients and rodent models are …

[HTML][HTML] Psilocybin for treatment-resistant depression: fMRI-measured brain mechanisms

RL Carhart-Harris, L Roseman, M Bolstridge… - Scientific reports, 2017‏ - nature.com
Psilocybin with psychological support is showing promise as a treatment model in psychiatry
but its therapeutic mechanisms are poorly understood. Here, cerebral blood flow (CBF) and …

Functional connectomics in depression: insights into therapies

Y Chai, YI Sheline, DJ Oathes, NL Balderston… - Trends in cognitive …, 2023‏ - cell.com
Depression is a common mental disorder characterized by heterogeneous cognitive and
behavioral symptoms. The emerging research paradigm of functional connectomics has …

Glutamate and gamma-aminobutyric acid systems in the pathophysiology of major depression and antidepressant response to ketamine

MS Lener, MJ Niciu, ED Ballard, M Park, LT Park… - Biological …, 2017‏ - Elsevier
In patients with major depressive disorder or bipolar disorder, abnormalities in excitatory
and/or inhibitory neurotransmission and neuronal plasticity may lead to aberrant functional …

Resting state brain network function in major depression–depression symptomatology, antidepressant treatment effects, future research

J Brakowski, S Spinelli, N Dörig, OG Bosch… - Journal of psychiatric …, 2017‏ - Elsevier
The alterations of functional connectivity brain networks in major depressive disorder (MDD)
have been subject of a large number of studies. Using different methodologies and focusing …

Functional reorganization of the default mode network across chronic pain conditions

MN Baliki, AR Mansour, AT Baria, AV Apkarian - PloS one, 2014‏ - journals.plos.org
Chronic pain is associated with neuronal plasticity. Here we use resting-state functional
magnetic resonance imaging to investigate functional changes in patients suffering from …

Depression, neuroimaging and connectomics: a selective overview

Q Gong, Y He - Biological psychiatry, 2015‏ - Elsevier
Depression is a multifactorial disorder with clinically heterogeneous features involving
disturbances of mood and cognitive function. Noninvasive neuroimaging studies have …

Looking for the self: phenomenology, neurophysiology and philosophical significance of drug-induced ego dissolution

R Millière - Frontiers in human neuroscience, 2017‏ - frontiersin.org
There is converging evidence that high doses of hallucinogenic drugs can produce
significant alterations of self-experience, described as the dissolution of the sense of self …