Arrhythmogenic cardiomyopathy is a genetic disorder characterized by the risk of life-
threatening arrhythmias, myocardial dysfunction and fibrofatty replacement of myocardial …

Intercellular communication is essential for proper cardiac function. Mechanical and
electrical activity need to be synchronized so that the work of individual myocytes transforms …

Abstract Nav1. 5, the pore forming α-subunit of the voltage-dependent cardiac Na+ channel,
is an integral membrane protein involved in the initiation and conduction of action potentials …

Rationale: The early description of the intercalated disc defined 3 structures, all of them
involved in cell-cell communication: desmosomes, gap junctions, and adherens junctions …

Rationale: The cardiac sodium channel Nav1. 5 plays a key role in excitability and
conduction. The 3 last residues of Nav1. 5 (Ser-Ile-Val) constitute a PDZ-domain binding …

Ion channel function is fundamental to the existence of life. In metazoans, the coordinate
activities of voltage-gated Na+ channels underlie cellular excitability and control neuronal …

The cardiac voltage-gated Na+ channel Nav1. 5 generates the cardiac Na+ current (INa).
Mutations in SCN5A, the gene encoding Nav1. 5, have been linked to many cardiac …

Gap junctions form electrical conduits between adjacent myocardial cells, permitting rapid
spatial passage of the excitation current essential to each heartbeat. Arrhythmogenic …

Objective Dravet syndrome is a severe form of intractable pediatric epilepsy with a high
incidence of SUDEP: S udden U nexpected D eath in epilepsy. Cardiac arrhythmias are a …

Rationale: In cardiomyocytes, NaV1. 5 and Kir2. 1 channels interact dynamically as part of
membrane bound macromolecular complexes. Objective: The objective of this study was to …