Ca2+-release channels are giant membrane proteins that control the release of Ca2+ from
the endoplasmic and sarcoplasmic reticulum. The two members, ryanodine receptors …

Crystallography supplies unparalleled detail on structural information critical for mechanistic
analyses; however, it is restricted to describing low energy conformations of …

EMAN is a scientific image processing package with a particular focus on single particle
reconstruction from transmission electron microscopy (TEM) images. It was first released in …

A method is presented for automated best-matching alignment of three-dimensional models
represented by ensembles of points. A normalized spatial discrepancy (NSD) is introduced …

Cryoelectron microscopy of biological molecules is among the hottest growth areas in
biophysics and structural biology at present, and Frank is arguably the most distinguished …

A novel method to flexibly fit atomic structures into electron microscopy (EM) maps using
molecular dynamics simulations is presented. The simulations incorporate the EM data as …

RNA virus infection is recognized by retinoic acid-inducible gene (RIG)-I–like receptors
(RLRs), RIG-I, and melanoma differentiation–associated gene 5 (MDA5) in the cytoplasm …

Prokaryotes have evolved multiple versions of an RNA-guided adaptive immune system that
targets foreign nucleic acids. In each case, transcripts derived from clustered regularly …

The CRISPR (clustered regularly interspaced short palindromic repeats) immune system in
prokaryotes uses small guide RNAs to neutralize invading viruses and plasmids. In …

The recently identified plant photoreceptor UVR8 (UV RESISTANCE LOCUS 8) triggers
regulatory changes in gene expression in response to ultraviolet-B (UV-B) light through an …