Crucial role of the transcription factors family activator protein 2 in cancer: current clue and views
C **, Y Luo, Z Liang, X Li, D Kołat, L Zhao… - Journal of Translational …, 2023 - Springer
The transcription factor family activator protein 2 (TFAP2) is vital for regulating both
embryonic and oncogenic development. The TFAP2 family consists of five DNA-binding …
embryonic and oncogenic development. The TFAP2 family consists of five DNA-binding …
Germline stem cells in human
H Cheng, D Shang, R Zhou - Signal transduction and targeted therapy, 2022 - nature.com
The germline cells are essential for the propagation of human beings, thus essential for the
survival of mankind. The germline stem cells, as a unique cell type, generate various states …
survival of mankind. The germline stem cells, as a unique cell type, generate various states …
Primate-specific transposable elements shape transcriptional networks during human development
The human genome contains more than 4.5 million inserts derived from transposable
elements (TEs), the result of recurrent waves of invasion and internal propagation …
elements (TEs), the result of recurrent waves of invasion and internal propagation …
Sequential enhancer state remodelling defines human germline competence and specification
Germline–soma segregation is a fundamental event during mammalian embryonic
development. Here we establish the epigenetic principles of human primordial germ cell …
development. Here we establish the epigenetic principles of human primordial germ cell …
METTL3 potentiates resistance to cisplatin through m6A modification of TFAP2C in seminoma
J Wei, Y Yin, J Zhou, H Chen, J Peng… - Journal of cellular …, 2020 - Wiley Online Library
Testicular germ cell tumours (TGCTs) rank as the most common malignancy in men aged 20‐
34 years, and seminomas are the most type of TGCTs. As a crucial anti‐tumour agent with …
34 years, and seminomas are the most type of TGCTs. As a crucial anti‐tumour agent with …
Origin and segregation of the human germline
A Castillo-Venzor, CA Penfold… - Life Science …, 2023 - life-science-alliance.org
Human germline–soma segregation occurs during weeks 2–3 in gastrulating embryos.
Although direct studies are hindered, here, we investigate the dynamics of human primordial …
Although direct studies are hindered, here, we investigate the dynamics of human primordial …
SOX17 in cellular reprogramming and cancer
SOX17 is a transcription factor directing the specification and development of the primitive
endoderm, primitive germ cells, definitive endoderm and, subsequently, is involved in the …
endoderm, primitive germ cells, definitive endoderm and, subsequently, is involved in the …
A hominoid-specific endogenous retrovirus may have rewired the gene regulatory network shared between primordial germ cells and naïve pluripotent cells
Mammalian germ cells stem from primordial germ cells (PGCs). Although the gene
regulatory network controlling the development of germ cells such as PGCs is critical for …
regulatory network controlling the development of germ cells such as PGCs is critical for …
[HTML][HTML] Molecular and epigenetic pathogenesis of germ cell tumors
MR Müller, MA Skowron, P Albers… - Asian Journal of Urology, 2021 - Elsevier
The development of germ cell tumors (GCTs) is a unique pathogenesis occurring at an early
developmental stage during specification, migration or colonization of primordial germ cells …
developmental stage during specification, migration or colonization of primordial germ cells …
PIM1 promotes hepatic conversion by suppressing reprogramming-induced ferroptosis and cell cycle arrest
Protein kinase-mediated phosphorylation plays a critical role in many biological processes.
However, the identification of key regulatory kinases is still a great challenge. Here, we …
However, the identification of key regulatory kinases is still a great challenge. Here, we …