post-ischemic permeability of the blood–brain barrier to amyloid and platelets as a factor in the maturation of Alzheimer's Disease-type brain neurodegeneration

R Pluta, B Miziak, SJ Czuczwar - International Journal of Molecular …, 2023 - mdpi.com
The aim of this review is to present evidence of the impact of ischemic changes in the blood–
brain barrier on the maturation of post-ischemic brain neurodegeneration with features of …

Advancements and Challenges in Antiamyloid Therapy for Alzheimer's Disease: A Comprehensive Review

SA Beshir, N Hussain, VB Menon… - International Journal …, 2024 - Wiley Online Library
Alzheimer's disease (AD) is a progressive neurodegenerative disorder caused by the
accumulation of amyloid‐beta (Aβ) proteins and neurofibrillary tangles in the brain. There …

Blood–Brain Barrier Breakdown in Alzheimer's Disease: Mechanisms and Targeted Strategies

AE Alkhalifa, NF Al-Ghraiybah, J Odum… - International Journal of …, 2023 - mdpi.com
The blood–brain barrier (BBB) is a unique and selective feature of the central nervous
system's vasculature. BBB dysfunction has been observed as an early sign of Alzheimer's …

The microbiota–gut–brain axis in Huntington's disease: pathogenic mechanisms and therapeutic targets

MN Ekwudo, C Gubert, AJ Hannan - The FEBS Journal, 2024 - Wiley Online Library
Huntington's disease (HD) is a currently incurable neurogenerative disorder and is typically
characterized by progressive movement disorder (including chorea), cognitive deficits …

Unveiling the impact of Aging on BBB and Alzheimer's disease: Factors and Therapeutic implications

VK Nelson, NK Jha, MV Nuli, S Gupta, S Kanna… - Ageing research …, 2024 - Elsevier
Alzheimer's disease (AD) is a highly prevalent neurodegenerative condition that has
devastating effects on individuals, often resulting in dementia. AD is primarily defined by the …

Adipose tissue as a therapeutic target for vascular damage in Alzheimer's disease

M Bettinetti‐Luque, L Trujillo‐Estrada… - British Journal of …, 2024 - Wiley Online Library
Adipose tissue has recently been recognized as an important endocrine organ that plays a
crucial role in energy metabolism and in the immune response in many metabolic tissues …

Patient-Derived Blood-Brain Barrier Model for Screening Copper Bis (thiosemicarbazone) Complexes as Potential Therapeutics in Alzheimer's Disease

JM Wasielewska, K Szostak, LE McInnes… - ACS chemical …, 2024 - ACS Publications
Alzheimer's disease (AD) is the most prevalent cause of dementia characterized by a
progressive cognitive decline. Addressing neuroinflammation represents a promising …

[HTML][HTML] Recent advances in brain delivery of synthetic and natural nano therapeutics: Reviving hope for Alzheimer's disease patients

DS Nady, U Bakowsky, SA Fahmy - Journal of Drug Delivery Science and …, 2023 - Elsevier
As the globe's population increases, the incidences of Alzheimer's disease (AD) are steadily
increasing. AD represents the most common neurological disorder and constitutes 60–70 …

Effects of low-intensity ultrasound opening the blood-brain barrier on Alzheimer's disease—a mini review

M Zhou, X Fu, B Ma, Z Chen, Y Cheng, L Liu… - Frontiers in …, 2023 - frontiersin.org
Due to the complex pathological mechanisms of Alzheimer's disease (AD), its treatment
remains a challenge. One of the major difficulties in treating AD is the difficulty for drugs to …

[HTML][HTML] Advancing neurological disorders therapies: Organic nanoparticles as a key to blood-brain barrier penetration

ZS Razavi, SS Alizadeh, FS Razavi, M Souri… - International Journal of …, 2025 - Elsevier
The blood–brain barrier (BBB) plays a vital role in protecting the central nervous system
(CNS) by preventing the entry of harmful pathogens from the bloodstream. However, this …