Drug discovery and development affects various aspects of human health and dramatically
impacts the pharmaceutical market. However, investments in a new drug often go …

Objective To summarize applications of natural language processing (NLP) in model
informed drug development (MIDD) and identify potential areas of improvement. Materials …

Gene and protein set enrichment analysis is a critical step in the analysis of data collected
from omics experiments. Enrichr is a popular gene set enrichment analysis web-server …

During early telencephalic development, intricate processes of regional patterning and
neural stem cell (NSC) fate specification take place. However, our understanding of these …

Aging increases the risk of liver diseases and systemic susceptibility to aging-related
diseases. However, cell type-specific changes and the underlying mechanism of liver aging …

Quercetin is a flavonoid with notable pharmacological effects and promising therapeutic
potential. Quercetin plays a significant role in neuroinflammation, which helps reduce …

Ethnopharmacological relevance Saffron, the dried stigma of Crocus sativus L., has a long
history of use in the treatment of depression in traditional Chinese medicine and Islamic …

Adrenal Cushing's syndrome is a disease of cortisol hypersecretion often caused by
mutations in protein kinase A catalytic subunit (PKAc). Using a personalized medicine …

The global spread of the SARS coronavirus 2 (SARS-CoV-2), its manifestation in human
hosts as a contagious disease, and its variants have induced a pandemic resulting in the …

Covalent amino acid modification significantly expands protein functional capability in
regulating biological processes. Tyrosine residues can undergo phosphorylation, sulfation …