Deregulated activity of BCR-ABL1, a nonreceptor tyrosine kinase encoded by the fusion
gene resulting from the t (9; 22)(q34; q11) chromosomal translocation, is thought to be the …

The cytoskeleton is a central factor contributing to various hallmarks of cancer. In recent
years, there has been increasing evidence demonstrating the involvement of actin …

Multiple myeloma (MM) is a biologically heterogeneous malignancy, however, the
mechanisms underlying this complexity are incompletely understood. We report an analysis …

Tyrosine kinase inhibitors (TKIs) targeting BCR-ABL1 have revolutionized therapy for
chronic myeloid leukemia (CML), paving the way for clinical development in other diseases …

Background BCR-ABL-independent drug resistance is a barrier to curative treatment of
chronic myeloid leukemia (CML). However, the molecular pathways underlying BCR-ABL …

Resistance to the BCR-ABL tyrosine kinase inhibitor (TKI) remains a challenge for curing the
disease in chronic myeloid leukemia (CML) patients as leukemia cells may survive through …

Small nucleolar RNAs (snoRNAs) are noncoding RNA molecules of highly variable size,
usually ranging from 60 to 150 nucleotides. They are classified into H/ACA box snoRNAs …

Local actin filament formation is indispensable for development of the dendritic arbor of
neurons. We show that, surprisingly, the action of single actin filament-promoting factors was …

Androgen receptor (AR) signaling is essential for prostate cancer progression and acquiring
resistance to hormone therapy. However, the molecular pathogenesis through AR activation …

Accurate prediction of malignancies is important in choosing therapeutic strategies.
Although there are many genetic and cytogenetic prognostic factors for acute myeloid …