Vascular tone of resistance arteries and arterioles determines peripheral vascular
resistance, contributing to the regulation of blood pressure and blood flow to, and within the …

Cerebral small vessel disease (cSVD) is the most common cause of vascular cognitive
impairment and affects all levels of the brain's vasculature. Features include diverse …

The calcium ion (Ca2+) is the simplest and most versatile intracellular messenger known.
The discovery of Ca2+ sparks and a related family of elementary Ca2+ signaling events has …

Different calcium signals in the endothelium and smooth muscle target different types of
Ca2+-sensitive K+ channels to modulate vascular function. These differential calcium …

The deficit in cerebral blood flow (CBF) seen in patients with hypertension-induced vascular
dementia is increasingly viewed as a therapeutic target for disease-modifying therapy …

The large-conductance, calcium-activated potassium channels (BK, also termed BKCa, Slo,
or MaxiK) distributed in both excitable and non-excitable cells are involved in many cellular …

Vascular smooth muscle (VSM) cells, endothelial cells (EC), and pericytes that form the
walls of vessels in the microcirculation express a diverse array of ion channels that play an …

The three subtypes of calcium‐activated potassium channels (KCa) of large, intermediate
and small conductance (BKCa, IKCa and SKCa) are present in the vascular wall. In healthy …

Potassium channels importantly contribute to the regulation of vascular smooth muscle
(VSM) contraction and growth. They are the dominant ion conductance of the VSM cell …

Large conductance, Ca 2+-activated potassium (BK) channels are widely expressed
throughout the animal kingdom and play important roles in many physiological processes …