Abstract Attenuated Total Reflection Fourier Transform Infrared (ATR-FTIR) spectroscopy is
a label-free, non-destructive technique that can be applied to a vast range of biological …

Alterations in protein structure may have profound effects on biological function. Analytical
techniques that permit characterization of proteins while maintaining their conformational …

MEDI4276 is a biparatopic tetravalent antibody targeting two nonoverlap** epitopes in
subdomains 2 and 4 of the HER2 ecto-domain, with site-specific conjugation to a tubulysin …

Size-exclusion chromatography employing aqueous mobile phases with volatile salts at
neutral pH combined with electrospray-ionization mass spectrometry (SEC-ESI-MS) is a …

Introduction: The development and optimization of antibody drug conjugates (ADCs) rely on
improving their analytical and bioanalytical characterization, by assessing critical quality …

The specific delivery of a drug to its site of action also known as targeted drug delivery is a
topic in the field of pharmaceutics studied for decades. One approach extensively …

| Several diseases exhibit a high degree of heterogeneity and diverse reprogramming of
cellular pathways. To address this complexity, additional strategies and technologies must …

During the last few years Antibody-Drug Conjugates (ADCs) have become one of the most
active and very promising therapeutic weapons. Lessons learned from the traditional …

Cation-exchange chromatography is a widely used approach to study charge heterogeneity
of monoclonal antibodies. Heterogeneity may arise both in vitro and in vivo because of the …

Cancer cells frequently overexpress specific surface receptors providing tumor growth and
survival which can be used for precise therapy. Targeting cancer cell receptors with protein …