Heart failure (HF) with preserved ejection fraction (HFpEF) is a multifactorial disease
accounting for a large and increasing proportion of all clinical HF presentations. As a clinical …

Heart failure with preserved ejection fraction (HFpEF) is characterized by signs and
symptoms of heart failure in the presence of a normal left ventricular ejection fraction …

Alzheimer's disease (AD) is a highly age-related cognitive decline frequently attacking the
elderly. Senescence-accelerated mouse-prone 8 (SAMP8) is an ideal model to study AD …

Cardiac ageing manifests as a decline in function leading to heart failure. At the cellular
level, ageing entails decreased replicative capacity and dysregulation of cellular processes …

With the global increase of the elderly population, the improvement of the treatment for
various aging-related diseases and the extension of a healthy lifespan have become some …

Icariin is a major active component of the traditional herb Epimedium, also known as Horny
Goat Weed. It has been extensively studied throughout the past several years and is known …

Cellular senescence is a cell cycle arrest in damaged or aged cells. Although this represents
a critical mechanism of tumor suppression, persistence of senescent cells during aging …

Vascular ageing, characterized by structural and functional changes in blood vessels of
which arterial stiffness and endothelial dysfunction are key components, is associated with …

At least one-half of the growing heart failure population consists of heart failure with
preserved ejection fraction (HFpEF). The limited therapeutic options, the complexity of the …

Progressive age-induced deterioration in the structure and function of the cardiovascular
system involves cardiac hypertrophy, diastolic dysfunction, myocardial fibrosis, arterial …