NMR-based metabolomics applied to ecotoxicology with zebrafish (Danio rerio) as a prominent model for metabolic profiling and biomarker discovery: Overviewing …

VA Porto, ER da Rocha Júnior, JS Ursulino… - Science of The Total …, 2023 - Elsevier
Metabolomics is an innovative approach used in the medical, toxicological, and biological
sciences. As an interdisciplinary topic, metabolomics and its relation with the environment …

Mass spectrometry-based zebrafish toxicometabolomics: a review of analytical and data quality challenges

KM da Silva, E Iturrospe, C Bars, D Knapen… - Metabolites, 2021 - mdpi.com
Metabolomics has achieved great progress over the last 20 years, and it is currently
considered a mature research field. As a result, the number of applications in toxicology …

Metabolomic profiling of zebrafish (Danio rerio) embryos exposed to the antibacterial agent triclosan

J Fu, Z Gong, BC Kelly - Environmental toxicology and …, 2019 - Wiley Online Library
Triclosan, a widely used antibacterial and antifungal agent, is ubiquitously detected in the
natural environment. There is increasing evidence that triclosan can produce cytotoxic …

Guidelines and considerations for building multidimensional libraries for untargeted MS-based metabolomics

KM da Silva, M van de Lavoir, R Robeyns, E Iturrospe… - Metabolomics, 2022 - Springer
Introduction Feature ann otation is crucial in untargeted metabolomics but remains a major
challenge. The large pool of metabolites collected under various instrumental conditions is …

1H NMR-based metabolomics approach reveals metabolic alterations in response to dietary imbalances in Megalobrama amblycephala

P Prathomya, W Prisingkorn, I Jakovlić, FY Deng… - Metabolomics, 2017 - Springer
Introduction High-fat and high-carbohydrate diets cause a number of metabolic disorders in
mammals. However, little is known about metabolomic changes caused by dietary …

Short-and medium-term exposures of diazepam induce metabolomic alterations associated with the serotonergic, dopaminergic, adrenergic and aspartic acid …

PA Markin, A Brito, NE Moskaleva, F Tagliaro… - … and Physiology Part D …, 2021 - Elsevier
Introduction Diazepam is a well-known psychoactive drug widely used worldwide for the
treatment of anxiety, seizures, alcohol withdrawal syndrome, muscle spasms, sleeplessness …

Evaluation and optimization of sample pretreatment for GC/MS-based metabolomics in embryonic zebrafish

SC Yan, ZF Chen, H Zhang, Y Chen, Z Qi, G Liu, Z Cai - Talanta, 2020 - Elsevier
Metabolomics tactics have been applied in the research associated with embryonic
zebrafish. However, the report regarding the evaluation of impacts of sample pretreatment …

Short-and long-term exposures of the synthetic cannabinoid 5F-APINAC induce metabolomic alterations associated with neurotransmitter systems and embryotoxicity …

PA Markin, A Brito, NE Moskaleva, F Tagliaro… - … and Physiology Part C …, 2021 - Elsevier
Introduction Synthetic cannabinoids are abused substances with strong psychoactive
effects. Little is known about the effects on neurotransmission and the toxicity of the second …

1H-NMR Metabolomics Analysis of the Effect of Rubusoside on Serum Metabolites of Golden Hamsters on a High-Fat Diet

L Li, M Jiang, Y Li, J Su, L Li, X Qu, L Fan - Molecules, 2020 - mdpi.com
Rubusoside is a natural sweetener and the active component of Rubus suavissimus. The
preventive and therapeutic effect of rubusoside on high-fat diet-induced (HFD) serum …

The effects of systemic and local fatty acid amide hydrolase and monoacylglycerol lipase inhibitor treatments on the metabolomic profile of lungs

R Abohalaka, TE Bozkurt, T Reçber… - Biomedical …, 2022 - Wiley Online Library
The contribution of the endocannabinoid system to both physiology and pathological
processes in the respiratory system makes it a promising target for inflammatory airway …