The essential role of tick salivary glands and saliva in tick feeding and pathogen transmission

L Šimo, M Kazimirova, J Richardson… - Frontiers in cellular and …, 2017 - frontiersin.org
As long-term pool feeders, ticks have developed myriad strategies to remain discreetly but
solidly attached to their hosts for the duration of their blood meal. The critical biological …

Tick salivary compounds: their role in modulation of host defences and pathogen transmission

M Kazimírová, I Štibrániová - Frontiers in cellular and infection …, 2013 - frontiersin.org
Ticks require blood meal to complete development and reproduction. Multifunctional tick
salivary glands play a pivotal role in tick feeding and transmission of pathogens. Tick …

Complement evasion by human pathogens

JD Lambris, D Ricklin, BV Geisbrecht - Nature Reviews Microbiology, 2008 - nature.com
The human immune system has developed an elaborate network of cascades for dealing
with microbial intruders. Owing to its ability to rapidly recognize and eliminate …

The role of saliva in tick feeding

IMB Francischetti, A Sa-Nunes, BJ Mans… - … in bioscience: a …, 2009 - pmc.ncbi.nlm.nih.gov
When attempting to feed on their hosts, ticks face the problem of host hemostasis (the
vertebrate mechanisms that prevent blood loss), inflammation (that can produce itching or …

Ticks and tick-borne pathogens at the cutaneous interface: host defenses, tick countermeasures, and a suitable environment for pathogen establishment

S Wikel - Frontiers in microbiology, 2013 - frontiersin.org
Ticks are unique among hematophagous arthropods by continuous attachment to host skin
and blood feeding for days; complexity and diversity of biologically active molecules …

The pathogenesis of lyme neuroborreliosis: from infection to inflammation

TA Rupprecht, U Koedel, V Fingerle, HW Pfister - Molecular medicine, 2008 - Springer
This review describes the current knowledge of the pathogenesis of acute Lyme
neuroborreliosis (LNB), from invasion to inflammation of the central nervous system. Borrelia …

Implication of haematophagous arthropod salivary proteins in host-vector interactions

A Fontaine, I Diouf, N Bakkali, D Missé, F Pagès… - Parasites & vectors, 2011 - Springer
The saliva of haematophagous arthropods contains an array of anti-haemostatic, anti-
inflammatory and immunomodulatory molecules that contribute to the success of the blood …

Complement evasion of pathogens: common strategies are shared by diverse organisms

PF Zipfel, R Würzner, C Skerka - Molecular immunology, 2007 - Elsevier
Infectious diseases represent a major health problem. Based on the limited efficacy of
existing drugs and vaccines and the increasing antibiotic resistance new strategies are …

TickSialoFam (TSFam): a database that helps to classify tick salivary proteins, a review on tick salivary protein function and evolution, with considerations on the tick …

JMC Ribeiro, BJ Mans - Frontiers in cellular and infection microbiology, 2020 - frontiersin.org
Tick saliva contains a complex mixture of peptides and non-peptides that counteract their
hosts' hemostasis, immunity, and tissue-repair reactions. Recent transcriptomic studies have …

Sialome diversity of ticks revealed by RNAseq of single tick salivary glands

J Perner, S Kropáčková, P Kopáček… - PLoS neglected …, 2018 - journals.plos.org
Ticks salivate while feeding on their hosts. Saliva helps blood feeding through host anti-
hemostatic and immunomodulatory components. Previous transcriptomic and proteomic …