Three-dimensional spheroids as in vitro preclinical models for cancer research
Most cancer biologists still rely on conventional two-dimensional (2D) monolayer culture
techniques to test in vitro anti-tumor drugs prior to in vivo testing. However, the vast majority …
techniques to test in vitro anti-tumor drugs prior to in vivo testing. However, the vast majority …
3D cell culture models as recapitulators of the tumor microenvironment for the screening of anti-cancer drugs
Simple Summary Three-dimensional (3D) cell culture models have been proposed as
alternatives for initial drug screening to increase drug development efficiency. In addition to …
alternatives for initial drug screening to increase drug development efficiency. In addition to …
Intrinsically disordered proteins: an overview
Many proteins and protein segments cannot attain a single stable three-dimensional
structure under physiological conditions; instead, they adopt multiple interconverting …
structure under physiological conditions; instead, they adopt multiple interconverting …
Promising applications of tumor spheroids and organoids for personalized medicine
Simple Summary Presently, the investigation of the tumor is carried out using different
models. One of the promising areas is the creation of 3D tumor models, such as spheroids …
models. One of the promising areas is the creation of 3D tumor models, such as spheroids …
Drug repurposing for viral cancers: A paradigm of machine learning, deep learning, and virtual screening‐based approaches
Cancer management is major concern of health organizations and viral cancers account for
approximately 15.4% of all known human cancers. Due to large number of patients, efficient …
approximately 15.4% of all known human cancers. Due to large number of patients, efficient …
Evaluation of biological activity of natural compounds: current trends and methods
Natural compounds have diverse structures and are present in different forms of life.
Metabolites such as tannins, anthocyanins, and alkaloids, among others, serve as a defense …
Metabolites such as tannins, anthocyanins, and alkaloids, among others, serve as a defense …
Recent advances in organ‐on‐chips integrated with bioprinting technologies for drug screening
Currently, the demand for more reliable drug screening devices has made scientists and
researchers develop novel potential approaches to offer an alternative to animal studies …
researchers develop novel potential approaches to offer an alternative to animal studies …
Tumor-derived systems as novel biomedical tools—turning the enemy into an ally
Cancer is a complex illness that presents significant challenges in its understanding and
treatment. The classic definition," a group of diseases characterized by the uncontrolled …
treatment. The classic definition," a group of diseases characterized by the uncontrolled …
Mouse tumor models for advanced cancer immunotherapy
Recent advances in the development of new methods of cancer immunotherapy require the
production of complex cancer animal models that reliably reflect the complexity of the tumor …
production of complex cancer animal models that reliably reflect the complexity of the tumor …
3D bioprinted drug-resistant breast cancer spheroids for quantitative in situ evaluation of drug resistance
S Hong, JM Song - Acta biomaterialia, 2022 - Elsevier
Drug-resistant cancer spheroids were fabricated by three-dimensional (3D) bioprinting for
the quantitative evaluation of drug resistance of cancer cells, which is a very important issue …
the quantitative evaluation of drug resistance of cancer cells, which is a very important issue …