Gut microbiota in colorectal cancer: mechanisms of action and clinical applications
Colorectal cancer (CRC) accounts for about 10% of all new cancer cases globally. Located
at close proximity to the colorectal epithelium, the gut microbiota comprises a large …
at close proximity to the colorectal epithelium, the gut microbiota comprises a large …
Cancer and the microbiome—influence of the commensal microbiota on cancer, immune responses, and immunotherapy
V Matson, CS Chervin, TF Gajewski - Gastroenterology, 2021 - Elsevier
The commensal microbiota has been implicated in the regulation of a diverse array of
physiological processes, both within the gastrointestinal tract and at distant tissue sites …
physiological processes, both within the gastrointestinal tract and at distant tissue sites …
A non-antibiotic-disrupted gut microbiome is associated with clinical responses to CD19-CAR-T cell cancer immunotherapy
Increasing evidence suggests that the gut microbiome may modulate the efficacy of cancer
immunotherapy. In a B cell lymphoma patient cohort from five centers in Germany and the …
immunotherapy. In a B cell lymphoma patient cohort from five centers in Germany and the …
Microbiota as predictor of mortality in allogeneic hematopoietic-cell transplantation
Background Relationships between microbiota composition and clinical outcomes after
allogeneic hematopoietic-cell transplantation have been described in single-center studies …
allogeneic hematopoietic-cell transplantation have been described in single-center studies …
The influence of the gut microbiome on cancer, immunity, and cancer immunotherapy
The microbiome is receiving significant attention given its influence on a host of human
diseases including cancer. Its role in response to cancer treatment is becoming increasingly …
diseases including cancer. Its role in response to cancer treatment is becoming increasingly …
Gut microbiome influences efficacy of PD-1–based immunotherapy against epithelial tumors
Immune checkpoint inhibitors (ICIs) targeting the PD-1/PD-L1 axis induce sustained clinical
responses in a sizable minority of cancer patients. We found that primary resistance to ICIs …
responses in a sizable minority of cancer patients. We found that primary resistance to ICIs …
Gut microbiome modulates response to anti–PD-1 immunotherapy in melanoma patients
Preclinical mouse models suggest that the gut microbiome modulates tumor response to
checkpoint blockade immunotherapy; however, this has not been well-characterized in …
checkpoint blockade immunotherapy; however, this has not been well-characterized in …
Acute graft-versus-host disease—biologic process, prevention, and therapy
When T cells from a bone marrow donor begin to attack the host within 3 months after
hematopoietic-cell transplantation, acute graft-versus-host disease results. The disease …
hematopoietic-cell transplantation, acute graft-versus-host disease results. The disease …
The oral microbiome and cancer
There is mounting evidence that members of the human microbiome are highly associated
with a wide variety of cancer types. Among oral cancers, oral squamous cell carcinoma …
with a wide variety of cancer types. Among oral cancers, oral squamous cell carcinoma …
Aspects of gut microbiota and immune system interactions in infectious diseases, immunopathology, and cancer
The microbiota consists of a dynamic multispecies community of bacteria, fungi, archaea,
and protozoans, bringing to the host organism a dowry of cells and genes more numerous …
and protozoans, bringing to the host organism a dowry of cells and genes more numerous …