Alcohol is one of the most widely consumed psychoactive drugs globally. Hazardous
drinking, defined by quantity and frequency of consumption, is associated with acute and …

A family of detoxifying enzymes called aldehyde dehydrogenases (ALDHs) has been a
subject of recent interest, as its role in detoxifying aldehydes that accumulate through …

Aims Aortic aneurysm/dissection (AAD) is a life-threatening disorder lacking effective
pharmacotherapeutic remedies. Aldehyde dehydrogenase 2 (ALDH2) polymorphism is tied …

The occurrence of more than 200 diseases, including cancer, can be attributed to alcohol
drinking. The global cancer deaths attributed to alcohol-consumption rose from 243,000 in …

Paleogenetics is an emerging field that resurrects ancestral proteins from now-extinct
organisms to test, in the laboratory, models of protein function based on natural history and …

Characterizing natural selection signatures and relationships with phenotype spectra is
important for understanding human evolution and both biological and pathological …

Asian Americans are one of the fastest-growing populations in the United States. A relatively
large subset of this population carries a unique loss-of-function point mutation in aldehyde …

Our understanding of human evolution has improved rapidly over recent decades, facilitated
by large‐scale cataloguing of genomic variability amongst both modern and archaic …

Flagella and motile cilia share a 9+ 2 microtubule-doublet axoneme structure, and
asthenozoospermia (reduced spermatozoa motility) is found in 76% of men with primary …

The ALDH2* 2 missense variant that commonly causes alcohol flushing reactions is the
single genetic polymorphism associated with the largest number of traits in humans. The …