The gut microbiota is essential to health and has recently become a target for live bacterial
cell biotherapies for various chronic diseases including metabolic syndrome, diabetes …

Ras homolog gene family member A (RhoA) is a small GTPase of the Rho family involved in
regulating multiple signal transduction pathways that influence a diverse range of cellular …

The Rho family of GTPases belongs to the Ras superfamily of low molecular weight (∼ 21
kDa) guanine nucleotide binding proteins. The most extensively studied members are RhoA …

Dendrite morphogenesis is a complex but well-orchestrated process and includes the
development of dendritic branches, forming characteristic dendrite arbors, and dendritic …

Many neurological disorders are characterised by structural changes in neuronal
connections, ranging from presymptomatic synaptic changes to the loss or rewiring of entire …

Alzheimer's disease (AD) is a highly prevalent neurodegenerative disorder characterized by
a progressive loss of cognition and the presence of two hallmark lesions, senile plaques …

Chondroitin sulfate proteoglycans (CSPGs) are a family of extracellular matrix molecules
with various functions in regulating tissue morphogenesis, cell division, and axon guidance …

Rho-associated coiled-coil kinase (ROCK), a serine/threonine kinase regulated by the small
GTPase RhoA, is involved in regulating cell migration, proliferation, and survival. Numerous …

Emerging evidence indicates that once established, synapses and dendrites can be
maintained for long periods, if not for the organism's entire lifetime. In contrast to the wealth …

Synapse degeneration occurs early in neurodegenerative diseases and correlates strongly
with cognitive decline in Alzheimer's disease (AD). The molecular mechanisms that trigger …