The introduction of in vitro nucleic acid amplification techniques, led by real-time PCR, into
the clinical microbiology laboratory has transformed the laboratory detection of viruses and …

DNA methylation has a substantial impact on gene expression, affecting the prognosis of
breast cancer (BC) patients dependent on molecular subtypes. In this study, we investigated …

Diabetic foot ulceration (DFU) is a devastating complication of diabetes whose pathogenesis
remains incompletely understood. Here, we profile 174,962 single cells from the foot …

Background: Cardiovascular risk in diabetes remains elevated despite glucose-lowering
therapies. We hypothesized that hyperglycemia induces trained immunity in macrophages …

The function of B cells in Alzheimer's disease (AD) is not fully understood. While
immunoglobulins that target amyloid beta (Aβ) may interfere with plaque formation and …

Tissue regeneration requires dynamic cellular adaptation to the wound environment. It is
currently unclear how this is orchestrated at the cellular level and how cell fate is affected by …

Genomic alterations shape cell phenotypes and the structure of tumor ecosystems in poorly
defined ways. To investigate these relationships, we used imaging mass cytometry to …

Objective Pneumonia accounts for more deaths than any other infectious disease
worldwide. The intestinal microbiota supports local mucosal immunity and is increasingly …

In fracture healing, skeletal and immune system are closely interacting through common cell
precursors and molecular mediators. It is thought that the initial inflammatory reaction, which …

The acute phase of sepsis is characterized by a strong inflammatory reaction. At later stages
in some patients, immunoparalysis may be encountered, which is associated with a poor …