Free radicals, reactive oxygen species, oxidative stress and its classification
VI Lushchak - Chemico-biological interactions, 2014 - Elsevier
Reactive oxygen species (ROS) initially considered as only damaging agents in living
organisms further were found to play positive roles also. This paper describes ROS …
organisms further were found to play positive roles also. This paper describes ROS …
The roles of NRF2 in modulating cellular iron homeostasis
MJ Kerins, A Ooi - Antioxidants & redox signaling, 2018 - liebertpub.com
Significance: Iron and oxygen are intimately linked: iron is an essential nutrient utilized as a
cofactor in enzymes for oxygen transport, oxidative phosphorylation, and metabolite …
cofactor in enzymes for oxygen transport, oxidative phosphorylation, and metabolite …
Role of reactive oxygen species (ROS) in therapeutics and drug resistance in cancer and bacteria
AT Dharmaraja - Journal of Medicinal Chemistry, 2017 - ACS Publications
Evading persistent drug resistance in cancer and bacteria is quintessential to restore health
in humans, and impels intervention strategies. A distinct property of the cancer phenotype is …
in humans, and impels intervention strategies. A distinct property of the cancer phenotype is …
NRF2 activation induces NADH-reductive stress, providing a metabolic vulnerability in lung cancer
Multiple cancers regulate oxidative stress by activating the transcription factor NRF2 through
mutation of its negative regulator, KEAP1. NRF2 has been studied extensively in KEAP1 …
mutation of its negative regulator, KEAP1. NRF2 has been studied extensively in KEAP1 …
Life, death, and autophagy in cancer: NF-κB turns up everywhere
Esca** programmed cell death is a hallmark of cancer. NF-κB transcription factors are key
regulator of cell survival and aberrant NF-κB signaling has been involved in the …
regulator of cell survival and aberrant NF-κB signaling has been involved in the …
Targeting transcription factors for cancer treatment
M Lambert, S Jambon, S Depauw… - Molecules, 2018 - mdpi.com
Transcription factors are involved in a large number of human diseases such as cancers for
which they account for about 20% of all oncogenes identified so far. For long time, with the …
which they account for about 20% of all oncogenes identified so far. For long time, with the …
TRIM25 promotes the cell survival and growth of hepatocellular carcinoma through targeting Keap1-Nrf2 pathway
Tumor cells often exhibit augmented capacity to maintain endoplasmic reticulum (ER)
homeostasis under adverse conditions, yet the underlying mechanisms are not well defined …
homeostasis under adverse conditions, yet the underlying mechanisms are not well defined …
Sulforaphane: its “coming of age” as a clinically relevant nutraceutical in the prevention and treatment of chronic disease
CA Houghton - Oxidative medicine and cellular longevity, 2019 - Wiley Online Library
A growing awareness of the mechanisms by which phytochemicals can influence upstream
endogenous cellular defence processes has led to intensified research into their potential …
endogenous cellular defence processes has led to intensified research into their potential …
Regulatory crosstalk between the oxidative stress-related transcription factor Nfe2l2/Nrf2 and mitochondria
I Ryoo, MK Kwak - Toxicology and applied pharmacology, 2018 - Elsevier
Mitochondria play essential roles in cellular bioenergetics, biosynthesis, and apoptosis.
During the process of respiration and oxidative phosphorylation, mitochondria utilize oxygen …
During the process of respiration and oxidative phosphorylation, mitochondria utilize oxygen …
[HTML][HTML] Chemical proteomics identifies druggable vulnerabilities in a genetically defined cancer
The transcription factor NRF2 is a master regulator of the cellular antioxidant response, and
it is often genetically activated in non-small-cell lung cancers (NSCLCs) by, for instance …
it is often genetically activated in non-small-cell lung cancers (NSCLCs) by, for instance …