Current success of immunotherapy in cancer has drawn attention to the subsets of TH cells
in the tumor which are critical for activation of anti-tumor response either directly by …

Acute inflammation is a physiological response to injury or infection, with a cascade of steps
that ultimately lead to the recruitment of immune cells to clear invading pathogens and heal …

Simple Summary Over the past decade, cell-based immunotherapy has become a powerful
strategy in solid cancer therapy. Tumor-infiltrating lymphocytes (TILs) are a group of …

CD8+ T cell exhaustion dampens antitumor immunity. Although several transcription factors
have been identified that regulate T cell exhaustion, the molecular mechanisms by which …

The advent of immunotherapy has made an indelible mark on the field of cancer therapy,
especially the application of immune checkpoint inhibitors in clinical practice. Although …

The molecular properties of CD8+ T cells that respond to SARS-CoV-2 infection are not fully
known. Here, we report on the single-cell transcriptomes of> 80,000 virus-reactive CD8+ T …

In pancreatic ductal adenocarcinoma (PDAC) patients, we show that response to radiation
therapy (RT) is characterized by increased IL-2Rβ and IL-2Rγ along with decreased IL-2Rα …

Simple Summary Over the past two decades, biological discoveries have transformed the
treatment strategies for renal cell carcinoma. These advances have led to the development …

CD8+ T cells play a crucial role in anti‐tumour immunity, but they often undergo exhaustion,
which affects the anti‐tumour activity of CD8+ T cells. The effect and mechanism of …

Cardiovascular disease is the leading cause of mortality worldwide, and atherosclerosis the
principal factor underlying cardiovascular events. Atherosclerosis is a chronic inflammatory …