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[HTML][HTML] Telomeres: history, health, and hallmarks of aging
D Chakravarti, KA LaBella, RA DePinho - Cell, 2021 - cell.com
The escalating social and economic burden of an aging world population has placed aging
research at center stage. The hallmarks of aging comprise diverse molecular mechanisms …
research at center stage. The hallmarks of aging comprise diverse molecular mechanisms …
Zebrafish patient avatars in cancer biology and precision cancer therapy
In precision oncology, two major strategies are being pursued for predicting clinically
relevant tumour behaviours, such as treatment response and emergence of drug resistance …
relevant tumour behaviours, such as treatment response and emergence of drug resistance …
Selective oxidative stress induces dual damage to telomeres and mitochondria in human T cells
Oxidative stress caused by excess reactive oxygen species (ROS) accelerates telomere
erosion and mitochondrial injury, leading to impaired cellular functions and cell death …
erosion and mitochondrial injury, leading to impaired cellular functions and cell death …
[HTML][HTML] BDE-209 and DBDPE induce male reproductive toxicity through telomere-related cell senescence and apoptosis in SD rat
X Li, J Liu, G Zhou, Y Sang, Y Zhang, L **g, Z Shi… - Environment …, 2021 - Elsevier
Abstract Decabrominated diphenyl ether (BDE-209) and decabromodiphenyl ethane
(DBDPE) are common flame retardants utilized in many kinds of electronic and textile …
(DBDPE) are common flame retardants utilized in many kinds of electronic and textile …
The genomics of inherited bone marrow failure: from mechanism to the clinic
T Wegman‐Ostrosky, SA Savage - British journal of …, 2017 - Wiley Online Library
The inherited bone marrow failure syndromes (IBMFS) typically present with significant
cytopenias in at least one haematopoietic cell lineage that may progress to pancytopenia …
cytopenias in at least one haematopoietic cell lineage that may progress to pancytopenia …
[HTML][HTML] Zebrafish as a model for fish diseases in aquaculture
LG Jørgensen - Pathogens, 2020 - mdpi.com
The use of zebrafish as a model for human conditions is widely recognized. Within the last
couple of decades, the zebrafish has furthermore increasingly been utilized as a model for …
couple of decades, the zebrafish has furthermore increasingly been utilized as a model for …
Reversal of brain aging by targeting telomerase: A nutraceutical approach
D Tsoukalas, AM Buga, AO Docea… - International …, 2021 - spandidos-publications.com
Telomeres, the protective caps of chromosomes, shorten with age, as telomerase, the
enzyme responsible for the compensation of telomere erosion, is inactive in the majority of …
enzyme responsible for the compensation of telomere erosion, is inactive in the majority of …
Microbial ageing and longevity
RZ Moger-Reischer, JT Lennon - Nature Reviews Microbiology, 2019 - nature.com
Longevity reflects the ability to maintain homeostatic conditions necessary for life as an
organism ages. A long-lived organism must contend not only with environmental hazards …
organism ages. A long-lived organism must contend not only with environmental hazards …
Electrical impedance myography detects age-related skeletal muscle atrophy in adult zebrafish
SB Rutkove, S Callegari, H Concepcion, T Mourey… - Scientific Reports, 2023 - nature.com
Age-related deficits in skeletal muscle function, termed sarcopenia, are due to loss of muscle
mass and changes in the intrinsic mechanisms underlying contraction. Sarcopenia is …
mass and changes in the intrinsic mechanisms underlying contraction. Sarcopenia is …
Telomere length and cardiovascular disease risk
The current research and results presented on telomere length may implicate that short
telomeres are causal risk factors for cardiovascular disease, partially through insulin …
telomeres are causal risk factors for cardiovascular disease, partially through insulin …