Epidemiology and treatment of multiple sclerosis in elderly populations

CB Vaughn, D Jakimovski, KS Kavak… - Nature Reviews …, 2019 - nature.com
The prevalence of multiple sclerosis (MS) and the age of affected patients are increasing
owing to increased longevity of the general population and the availability of effective …

Interplay between age and neuroinflammation in multiple sclerosis: effects on motor and cognitive functions

A Musella, A Gentile, FR Rizzo, F De Vito… - Frontiers in aging …, 2018 - frontiersin.org
Aging is one of the main risk factors for the development of many neurodegenerative
diseases. Emerging evidence has acknowledged neuroinflammation as potential trigger of …

CSF cytokines in aging, multiple sclerosis, and dementia

WT Hu, JC Howell, T Ozturk, U Gangishetti… - Frontiers in …, 2019 - frontiersin.org
Inflammation is a common process involved in aging, multiple sclerosis (MS), and age-
related neurodegenerative disorders such as Alzheimer's disease (AD) and Parkinson's …

Effects of exercise in people with multiple sclerosis: a systematic review and meta-analysis

L Du, H **, S Zhang, Y Zhou, X Tao, Y Lv… - Frontiers in public …, 2024 - frontiersin.org
Background A growing body of studies have examined the effect of exercise in people with
multiple sclerosis (MS), while findings of available studies were conflicting. This meta …

Aging with multiple sclerosis: prevalence and profile of cognitive impairment

M Branco, L Ruano, E Portaccio, B Goretti… - Neurological …, 2019 - Springer
Background The increase in life expectancy of patients with multiple sclerosis (MS) requires
a better knowledge of disease features in the older patients group. Objective To describe the …

[HTML][HTML] Lower extremity muscle power–A critical determinant of physical function in aging and multiple sclerosis

RAW Stagsted, C Ramari, AG Skjerbaek, C Thrue… - Experimental …, 2021 - Elsevier
Background and purpose In aging, lower extremity muscle power is undoubtedly one of the
most important parameters of neuromuscular function implicating lower extremity physical …

Physical activity and walking performance across the lifespan among adults with multiple sclerosis

JF Baird, KLJ Cederberg, EM Sikes, SL Silveira… - Multiple sclerosis and …, 2019 - Elsevier
Background There is consistent evidence of an association between physical activity and
walking performance in persons with multiple sclerosis (MS). To date, this relationship has …

Lower extremity muscle strength across the adult lifespan in multiple sclerosis: implications for walking and stair climbing capacity

PS Sieljacks, CA Søberg, AS Michelsen… - Experimental …, 2020 - Elsevier
Introduction Persons with multiple sclerosis (pwMS) accumulate impairments in muscle
strength and limitations in physical function as the disease progresses. The same symptoms …

Biological determinants impact the neurovascular toxicity of nicotine and tobacco smoke: A pharmacokinetic and pharmacodynamics perspective

SR Archie, S Sharma, E Burks, T Abbruscato - Neurotoxicology, 2022 - Elsevier
Accumulating evidence suggests that the detrimental effect of nicotine and tobacco smoke
on the central nervous system (CNS) is caused by the neurotoxic role of nicotine on blood …

[HTML][HTML] Effects of power training in older patients with multiple sclerosis on neurodegeneration, neuromuscular function, and physical function. A study protocol for the …

T Gaemelke, C Laustsen, P Feys, L Folkestad… - Contemporary Clinical …, 2024 - Elsevier
Introduction Approximately one-third of all persons with multiple sclerosis (pwMS) are older,
ie, having an age≥ 60 years. Whilst ageing and MS separately elicit deteriorating effects on …