Oligodendrocytes and Schwann cells are highly specialized glial cells that wrap axons with
a multilayered myelin membrane for rapid impulse conduction. Investigators have recently …

The largest pool of free cholesterol in mammals resides in myelin membranes. Myelin
facilitates rapid saltatory impulse propagation by electrical insulation of axons. This function …

Major depressive disorder is one of the most common and devastating psychiatric disorders.
To identify candidate mechanisms for major depressive disorder, we compared gene …

Two proteolipid proteins, PLP and DM20, are the major membrane components of central
nervous system (CNS) myelin. Mutations of the X-linked PLP/DM20 gene cause …

The interferon-regulated mouse Mx gene encodes the 72-kilodalton nuclear Mx protein that
selectively inhibits influenza virus replication. Mice carrying Mx+ alleles synthesize Mx …

Pelizaeus-Merzbacher disease (PMD) and its allelic disorder, spastic paraplegia type 2
(SPG2), are among the best-characterized dysmyelinating leukodystrophies of the central …

Using homologous recombination in embryonic stem cells, we have generated mice with a
null mutation in the gene encoding the myelin-associated glycoprotein (MAG), a recognition …

Proteolipid protein (PLP) is the major myelin membrane protein of the central nervous
system. We have isolated a copy of an alternatively spliced PLP gene transcript from a …

Proteolipid protein (PLP) is an integral membrane protein of CNS myelin. Mutations of the X
chromosome-linked PLP gene cause glial cell death and myelin deficiency in jimpy mice …

Shiverer (shi/shi) is an autosomal recessive mouse mutation that produces a shivering
phenotype in affected mice. A shivering gait can be seen from a few weeks after birth until …