Caspases are a highly conserved family of cysteine-aspartyl proteases known for their
essential roles in regulating apoptosis, inflammation, cell differentiation, and proliferation …

Non-coding RNAs (ncRNAs), generated from nonprotein coding DNA sequences, constitute
98–99% of the human genome. Non-coding RNAs encompass diverse functional classes …

Allosteric drugs have been attracting increasing interest over the past few years. In this
context, it is common practice to use high-throughput screening for the discovery of non …

Cancer genomes are rife with genetic variants; one key outcome of this variation is
widespread gain-of-cysteine mutations. These acquired cysteines can be both driver …

Computational chemistry has come of age in drug discovery. Indeed, most pharmaceutical
development programs rely on computer-based data and results at some point. Herein, we …

The recent pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-
CoV-2) highlighted a critical need to discover more effective antivirals. While therapeutics for …

Helicases, classified into six superfamilies, are mechanoenzymes that utilize energy derived
from ATP hydrolysis to remodel DNA and RNA substrates. These enzymes have key roles in …

DnaK is the bacterial homolog of Hsp70, an ATP-dependent chaperone that helps cofactor
proteins to catalyze nascent protein folding and salvage misfolded proteins. In the pathogen …

The accumulation and aggregation of the microtubule-associated protein tau (tau) into
intracellular neuronal tangles are a hallmark of a range of progressive neurodegenerative …

The rate-limiting serine biogenesis enzyme PHGDH is overexpressed in cancers. Both
serine withdrawal and genetic/pharmacological inhibition of PHGDH have demonstrated …