Thalamic regulation of switching between cortical representations enables cognitive flexibility
Interactions between the prefrontal cortex (PFC) and mediodorsal thalamus are critical for
cognitive flexibility, yet the underlying computations are unknown. To investigate …
cognitive flexibility, yet the underlying computations are unknown. To investigate …
[HTML][HTML] Disrupted place cell remap** and impaired grid cells in a knockin model of Alzheimer's disease
Patients with Alzheimer's disease (AD) suffer from spatial memory impairment and
wandering behavior, but the brain circuit mechanisms causing such symptoms remain …
wandering behavior, but the brain circuit mechanisms causing such symptoms remain …
[HTML][HTML] An ultra-sensitive step-function opsin for minimally invasive optogenetic stimulation in mice and macaques
Optogenetics is among the most widely employed techniques to manipulate neuronal
activity. However, a major drawback is the need for invasive implantation of optical fibers. To …
activity. However, a major drawback is the need for invasive implantation of optical fibers. To …
Prefrontal cortex regulates sensory filtering through a basal ganglia-to-thalamus pathway
To make adaptive decisions, organisms must appropriately filter sensory inputs, augmenting
relevant signals and suppressing noise. The prefrontal cortex (PFC) partly implements this …
relevant signals and suppressing noise. The prefrontal cortex (PFC) partly implements this …
Experience-dependent resonance in amygdalo-cortical circuits supports fear memory retrieval following extinction
Learned fear and safety are associated with distinct oscillatory states in the basolateral
amygdala (BLA) and medial prefrontal cortex (mPFC). To determine if and how these …
amygdala (BLA) and medial prefrontal cortex (mPFC). To determine if and how these …
[HTML][HTML] Understanding the circuit basis of cognitive functions using mouse models
Understanding how cognitive functions arise from computations occurring in the brain
requires the ability to measure and perturb neural activity while the relevant circuits are …
requires the ability to measure and perturb neural activity while the relevant circuits are …
The development of piezoelectric inchworm actuator clamped with magnetorheological elastomer and its potential application in brain–computer interface …
The piezoelectric inchworm actuator with high-positioning accuracy and large output force is
a potential device to implant microelectrode in the invasive brain–computer interface (BCI) …
a potential device to implant microelectrode in the invasive brain–computer interface (BCI) …
In vivo recordings in freely behaving mice using independent silicon probes targeting multiple brain regions
In vivo recordings in freely behaving animals are crucial to understand the neuronal circuit
basis of behavior. Although current multi-channel silicon probes provide unparalleled …
basis of behavior. Although current multi-channel silicon probes provide unparalleled …
Combinatorial targeting of distributed forebrain networks reverses noise hypersensitivity in a model of autism spectrum disorder
Autism spectrum disorder (ASD) is associated with noise hypersensitivity, the suboptimal
extraction of meaningful signals in noisy environments. Because sensory filtering can …
extraction of meaningful signals in noisy environments. Because sensory filtering can …
Medial entorhinal cortex excitatory neurons are necessary for accurate timing
The hippocampal region has long been considered critical for memory of time, and recent
evidence shows that network operations and single-unit activity in the hippocampus and …
evidence shows that network operations and single-unit activity in the hippocampus and …