ACE2: the major cell entry receptor for SARS-CoV-2

F Scialo, A Daniele, F Amato, L Pastore, MG Matera… - Lung, 2020 - Springer
Despite the unprecedented effort of the scientific community, the novel SARS-CoV-2 virus
has infected more than 46 million people worldwide, killing over one million two hundred …

Anosmia in COVID-19: underlying mechanisms and assessment of an olfactory route to brain infection

R Butowt, CS von Bartheld - The Neuroscientist, 2021 - journals.sagepub.com
In recent months it has emerged that the novel coronavirus—responsible for the COVID-19
pandemic—causes reduction of smell and taste in a large fraction of patients. The …

Broad host range of SARS-CoV-2 predicted by comparative and structural analysis of ACE2 in vertebrates

J Damas, GM Hughes, KC Keough, CA Painter… - Proceedings of the …, 2020 - pnas.org
The novel coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is
the cause of COVID-19. The main receptor of SARS-CoV-2, angiotensin I converting enzyme …

Genetics insight for COVID-19 susceptibility and severity: a review

I Fricke-Galindo, R Falfán-Valencia - Frontiers in immunology, 2021 - frontiersin.org
Coronavirus disease (COVID-19) presents a broad spectrum of clinical manifestations
ranging from an asymptomatic to a severe clinical course. The host genetic background …

Prevalence of chemosensory dysfunction in COVID-19 patients: a systematic review and meta-analysis reveals significant ethnic differences

CS von Bartheld, MM Hagen… - ACS chemical …, 2020 - ACS Publications
A significant proportion of people who test positive for COVID-19 have chemosensory
deficits. However, the reported prevalence of these deficits in smell and taste varies widely …

Just 2% of SARS-CoV-2− positive individuals carry 90% of the virus circulating in communities

Q Yang, TK Saldi, PK Gonzales, E Lasda… - Proceedings of the …, 2021 - pnas.org
We analyze data from the fall 2020 pandemic response efforts at the University of Colorado
Boulder, where more than 72,500 saliva samples were tested for severe acute respiratory …

The role of host genetics in the immune response to SARS‐CoV‐2 and COVID‐19 susceptibility and severity

IG Ovsyannikova, IH Haralambieva… - Immunological …, 2020 - Wiley Online Library
This article provides a review of studies evaluating the role of host (and viral) genetics
(including variation in HLA genes) in the immune response to coronaviruses, as well as the …

Human ACE2 receptor polymorphisms and altered susceptibility to SARS-CoV-2

K Suryamohan, D Diwanji, EW Stawiski… - Communications …, 2021 - nature.com
COVID-19 is a respiratory illness caused by a novel coronavirus called SARS-CoV-2. The
viral spike (S) protein engages the human angiotensin-converting enzyme 2 (ACE2) …

Initial whole-genome sequencing and analysis of the host genetic contribution to COVID-19 severity and susceptibility

F Wang, S Huang, R Gao, Y Zhou, C Lai, Z Li, W **an… - Cell discovery, 2020 - nature.com
The COVID-19 pandemic has accounted for millions of infections and hundreds of thousand
deaths worldwide in a short-time period. The patients demonstrate a great diversity in …

ACE2/ADAM17/TMPRSS2 interplay may be the main risk factor for COVID-19

D Zipeto, JF Palmeira, GA Argañaraz… - Frontiers in …, 2020 - frontiersin.org
The Coronavirus Disease 2019 (COVID-19) has already caused hundreds of thousands of
deaths worldwide in a few months. Cardiovascular disease, hypertension, diabetes and …