BACKGROUND Spermatogenesis generates a small and highly specialised type of cell that
is apparently incapable of transcription and translation. For many years, this dogma was …

The term non-coding RNA (ncRNA) is commonly employed for RNA that does not encode a
protein, but this does not mean that such RNAs do not contain information nor have function …

BACKGROUND Spermatozoa are highly differentiated, transcriptionally inert cells
characterized by a compact nucleus with minimal cytoplasm. Nevertheless they contain a …

Recently, it was discovered that non-protein-coding RNAs (ncRNAs) represent the majority
of the human transcripts. Regulatory role of many classes of ncRNAs is broadly recognized; …

microRNAs (miRNA) are recognized as regulators of gene expression during development
and cell differentiation as well as biomarkers of disease. Development of rapid and sensitive …

It has been widely acknowledged that non-coding RNAs are master-regulators of genomic
functions. However, the significance of the presence of ncRNA within introns has not …

Epigenetic deregulation at a number of genomic loci is one of the hallmarks of cancer. A role
for some RNA molecules in guiding repressive polycomb complex PRC2 to specific …

It is usually thought that the development of complex organisms is controlled by protein
regulatory factors and morphogenetic signals exchanged between cells and differentiating …

Background RNAs transcribed from intronic regions of genes are involved in a number of
processes related to post-transcriptional control of gene expression. However, the …

Long noncoding RNAs (lncRNAs) have emerged as an important class of molecules that
regulate gene expression at epigenetic, transcriptional, and post-transcriptional levels …