Type 2 diabetes is a metabolic, chronic disorder characterized by insulin resistance and
elevated blood glucose levels. Although a large drug portfolio exists to keep the blood …

Type 2 diabetes and major depressive disorder (MDD) are the leading causes of disability
worldwide and have a high comorbidity rate with fatal outcomes. Despite the long …

To date, the miRNA expression profile of plasma exosomes in women whose pregnancy is
complicated by gestational diabetes mellitus (GDM) has not been fully clarified. In this study …

Insulin secretion is critical for glucose homeostasis, and increased levels of the precursor
proinsulin relative to insulin indicate pancreatic islet beta-cell stress and insufficient insulin …

Purpose Type 2 diabetes mellitus is characterized by insulin resistance and β-cell
dysfunction. Elevated free fatty acids-induced lipotoxicity may play a vital role in the …

The number of people with diabetes worldwide is increasing annually, resulting in a serious
economic burden. Insulin resistance is a major pathology in the early onset of diabetes …

Insulin receptor (Insr) protein is present at higher levels in pancreatic β-cells than in most
other tissues, but the consequences of β-cell insulin resistance remain enigmatic. Here, we …

There is a growing understanding that the early phases of type 1 diabetes (T1D) are
characterised by a deleterious dialogue between the pancreatic beta cells and the immune …

The sheer amplitude of biological actions of insulin-like growth factor I (IGF-1) affecting all
type of cells in all tissues suggests a vast signaling landscape for this ubiquitous humoral …

Objectives To find plasma biomarkers prognostic of type 2 diabetes, which could also inform
on pancreatic β-cell deregulations or defects in the function of insulin target tissues. Methods …