Stroke is the world's second leading cause of mortality, with a high incidence of severe
morbidity in surviving victims. There are currently relatively few treatment options available …

Introduction: Hypoxic ischemic encephalopathy (HIE) is the most important reason for
morbidity and mortality in term-born infants. Understanding pathophysiology of the brain …

The endovascular perforation rodent model for experimental subarachnoid hemorrhage
(SAH) studies is criticized for lack of control over bleeding. Presently, there is no practical …

Background: Pretreatment with statins has been shown to reduce brain injury in cerebral
ischemia. In this controlled randomized study, we investigated the influence of statin …

Neuroprotection seeks to restrict injury to the brain parenchyma following an ischaemic
insult by preventing salvageable neurons from dying. The concept of neuroprotection has …

This study was undertaken to evaluate the effect of simvastatin, a cholesterol-lowering
agent, on the Akt-mediated signaling pathway and neurogenesis in the dentate gyrus (DG) …

Stroke is a threatening cerebrovascular disease caused by thrombus with high morbidity
and mortality rates. Neutrophils are the first to be recruited in the brain after stroke, which …

Neuroprotection aims to prevent salvageable neurons from dying. Despite showing efficacy
in experimental stroke studies, the concept of neuroprotection has failed in clinical trials …

Major depressive disorder (MDD) is associated with cognitive dysfunction encompassing
several domains, including memory, executive function, processing speed and attention …

Deregulation of matrix metalloproteinases (MMPs), the largest class of human proteases,
has been implicated in brain damage in both animal and human studies. Some MMPs are …