Transient receptor potential (TRP) channels are multifunctional signalling molecules with
many roles in sensory perception and cellular physiology. Therefore, it is not surprising that …

Introduction Chronic pain affects approximatively 30–50% of the population globally.
Pathologies such as migraine, diabetic neuropathy, nerve injury and treatment with …

Background Complex regional pain syndrome type-I (CRPS-I) causes excruciating pain that
affect patients' life quality. However, the mechanisms underlying CRPS-I are incompletely …

The transient receptor potential ankyrin 1 (TRPA1), a member of the TRP superfamily of
channels, is primarily localized in a subpopulation of primary sensory neurons of the …

The transient receptor potential ankyrin 1 (TRPA1) channel is a non-selective cation channel
that senses irritant chemicals. Its activation is closely associated with pain, inflammation, and …

Chronic pain is a common symptom experienced during cancer progression. Additionally,
some patients experience bone pain caused by cancer metastasis, which further …

Recently, increasing numbers of studies have demonstrated that transient receptor potential
ankyrin 1 (TRPA1) can be used as a potential target for the treatment of inflammatory …

Ion channels play a crucial role in a wide range of biological processes, including cell cycle
regulation and cancer progression. In particular, the transient receptor potential (TRP) family …

Neuropathic pain (NPP) is a common syndrome associated with most forms of cancer, which
poses a serious threat to human health. NPP may persist even after the nociceptive …

Abstract Complex Regional Pain Syndrome (CRPS) is an excess and/or prolonged pain and
inflammation condition that follows an injury to a limb. The pathogenesis of CRPS is …