An Ancient Yeast for Young Geneticists: A Primer on the Schizosaccharomyces pombe Model System
The fission yeast Schizosaccharomyces pombe is an important model organism for the study
of eukaryotic molecular and cellular biology. Studies of S. pombe, together with studies of its …
of eukaryotic molecular and cellular biology. Studies of S. pombe, together with studies of its …
Evolutionary mysteries in meiosis
Meiosis is a key event of sexual life cycles in eukaryotes. Its mechanistic details have been
uncovered in several model organisms, and most of its essential features have received …
uncovered in several model organisms, and most of its essential features have received …
Common SNPs explain a large proportion of the heritability for human height
SNPs discovered by genome-wide association studies (GWASs) account for only a small
fraction of the genetic variation of complex traits in human populations. Where is the …
fraction of the genetic variation of complex traits in human populations. Where is the …
Map** autism risk loci using genetic linkage and chromosomal rearrangements
Nature genetics, 2007 - nature.com
Autism spectrum disorders (ASDs) are common, heritable neurodevelopmental conditions.
The genetic architecture of ASDs is complex, requiring large samples to overcome …
The genetic architecture of ASDs is complex, requiring large samples to overcome …
Sex differences in the recombination landscape
Sex differences in overall recombination rates are well known, but little theoretical or
empirical attention has been given to how and why sexes differ in their recombination …
empirical attention has been given to how and why sexes differ in their recombination …
Assumption-free estimation of heritability from genome-wide identity-by-descent sharing between full siblings
The study of continuously varying, quantitative traits is important in evolutionary biology,
agriculture, and medicine. Variation in such traits is attributable to many, possibly interacting …
agriculture, and medicine. Variation in such traits is attributable to many, possibly interacting …
MYH9 is associated with nondiabetic end-stage renal disease in African Americans
As end-stage renal disease (ESRD) has a four times higher incidence in African Americans
compared to European Americans, we hypothesized that susceptibility alleles for ESRD …
compared to European Americans, we hypothesized that susceptibility alleles for ESRD …
Whole population, genome-wide map** of hidden relatedness
We present GERMLINE, a robust algorithm for identifying segmental sharing indicative of
recent common ancestry between pairs of individuals. Unlike methods with comparable …
recent common ancestry between pairs of individuals. Unlike methods with comparable …
Extended tracts of homozygosity in outbred human populations
Long tracts of consecutive homozygous single nucleotide polymorphisms (SNPs) can arise
in the genome through a number of mechanisms. These include inbreeding in which an …
in the genome through a number of mechanisms. These include inbreeding in which an …
Recent human effective population size estimated from linkage disequilibrium
Effective population size (Ne) determines the amount of genetic variation, genetic drift, and
linkage disequilibrium (LD) in populations. Here, we present the first genome-wide …
linkage disequilibrium (LD) in populations. Here, we present the first genome-wide …