Myocardial fibrosis, the expansion of the cardiac interstitium through deposition of
extracellular matrix proteins, is a common pathophysiologic companion of many different …

Cardiac fibrosis is a common pathophysiologic companion of most myocardial diseases,
and is associated with systolic and diastolic dysfunction, arrhythmogenesis, and adverse …

Rationale: The initial hypertrophy response to cardiac pressure overload is considered
compensatory, but with sustained stress, it eventually leads to heart failure. Recently, a role …

In patients with diabetes, myocardial fibrosis may contribute to the pathogenesis of heart
failure and arrhythmogenesis, increasing ventricular stiffness and delaying conduction …

Rationale: Systemic inflammation compromises the reparative properties of endothelial
progenitor cell (EPC) and their exosomes on myocardial repair, although the underlying …

Cardiovascular disease is the leading cause of morbidity and mortality world-wide. Recently,
the role of inflammation in the progression of diseases has significantly attracted …

Conduction disorders and arrhythmias remain difficult to treat and are increasingly prevalent
owing to the increasing age and body mass of the general population, because both are risk …

Cardiac fibrosis, a common pathophysiologic process in most heart diseases, refers to an
excess of extracellular matrix (ECM) deposition by cardiac fibroblasts (CFs), which can lead …

Kidney disease is a global health problem with high mortality and socioeconomic burden,
including acute kidney injury (AKI), chronic kidney disease (CKD), diabetic nephropathy …

Heart failure (HF) has been traditionally viewed as a disease of the cardiac muscle
associated with systemic inflammation. Burgeoning evidence implicates immune effector …