Disturbed cholesterol homeostasis plays critical roles in the development of multiple
diseases, such as cardiovascular diseases (CVD), neurodegenerative diseases and …

Mammalian adipose tissue can be divided into two major types, namely, white adipose
tissue (WAT) and brown adipose tissue (BAT). According to classical view, the main function …

Steatotic liver disease (SLD) displays a dynamic and complex disease phenotype.
Consequently, the metabolic dysfunction-associated steatotic liver disease …

Background Glucagon-like peptide-1 receptor (GLP-1R) agonists are approved for the
treatment of type 2 diabetes and obesity and elicit robust improvements in glycemic control …

The liver is crucial for the maintenance of normal glucose homeostasis—it produces glucose
during fasting and stores glucose postprandially. However, these hepatic processes are …

OBJECTIVE Sodium–glucose cotransporter 2 (SGLT-2) inhibitors have been shown to
reduce liver fat in rodent models. Data regarding the effect of SGLT-2 inhibitors on human …

NAFLD is closely linked with hepatic insulin resistance. Accumulation of hepatic
diacylglycerol activates PKC-ε, impairing insulin receptor activation and insulin-stimulated …

It has been known for a long time that thyroid hormones have prominent effects on hepatic
fatty acid and cholesterol synthesis and metabolism. Indeed, hypothyroidism has been …

Obesity is a serious and growing worldwide health challenge. Healthy lifestyle choices are
the foundation of obesity treatment. However, weight loss can lead to physiological …

In the last two decades we have witnessed sizable progress in defining the role of
gastrointestinal signals in the control of glucose and energy homeostasis. Specifically, the …