The rapid emergence of antifungal-resistant human-pathogenic fungi

SR Lockhart, A Chowdhary, JAW Gold - Nature Reviews Microbiology, 2023 - nature.com
During recent decades, the emergence of pathogenic fungi has posed an increasing public
health threat, particularly given the limited number of antifungal drugs available to treat …

Neutrophil extracellular traps in homeostasis and disease

H Wang, SJ Kim, Y Lei, S Wang, H Wang… - … and Targeted Therapy, 2024 - nature.com
Neutrophil extracellular traps (NETs), crucial in immune defense mechanisms, are
renowned for their propensity to expel decondensed chromatin embedded with inflammatory …

Interplay of cytokines and chemokines in aspergillosis

J Shankar, R Thakur, KV Clemons, DA Stevens - Journal of Fungi, 2024 - mdpi.com
Aspergillosis is a fungal infection caused by various species of Aspergillus, most notably A.
fumigatus. This fungus causes a spectrum of diseases, including allergic bronchopulmonary …

[HTML][HTML] Nanotechnology-based drug delivery systems to control bacterial-biofilm-associated lung infections

Y Guo, Z Mao, F Ran, J Sun, J Zhang, G Chai, J Wang - Pharmaceutics, 2023 - mdpi.com
Airway mucus dysfunction and impaired immunological defenses are hallmarks of several
lung diseases, including asthma, cystic fibrosis, and chronic obstructive pulmonary …

Aspergillus fumigatus conidial surface-associated proteome reveals factors for fungal evasion and host immunity modulation

CF Pinzan, C Valero, PA de Castro, JL da Silva… - Nature …, 2024 - nature.com
Aspergillus fumigatus causes aspergillosis and relies on asexual spores (conidia) for
initiating host infection. There is scarce information about A. fumigatus proteins involved in …

[HTML][HTML] Diagnosis of chronic pulmonary aspergillosis: clinical, radiological or laboratory?

A Barac, A Vujovic, A Drazic, G Stevanovic, B Paglietti… - Journal of Fungi, 2023 - mdpi.com
Chronic pulmonary aspergillosis (CPA) is a chronic progressive lung disease associated
with a poor prognosis and a 5-year mortality rate of approximately 40–50%. The disease is …

Antifungal and Antivirulence Activity of Vanillin and Tannic Acid Against Aspergillus fumigatus and Fusarium solani

AL Ríos-López, J Dávila-Aviña, GM González… - Current …, 2024 - Springer
Aspergillus fumigatus and Fusarium solani infections have become severe health threat;
both pathogens are considered a priority due to the increasing emergence of antifungal …

The cytochrome P450 reductase CprA is a rate-limiting factor for Cyp51A-mediated azole resistance in Aspergillus fumigatus

A Kühbacher, P Merschak, H Haas… - Antimicrobial agents …, 2023 - journals.asm.org
Azole antifungals remain the “gold standard” therapy for invasive aspergillosis. The world-
wide emergence of isolates resistant to this drug class, however, developed into a steadily …

Pulmonary aspergillosis in people with cystic fibrosis

C Schwarz, PN Eschenhagen, JG Mainz… - … in Respiratory and …, 2024 - thieme-connect.com
In the last decade, fungal respiratory diseases have been increasingly investigated for their
impact on the clinical course of people with cystic fibrosis (CF), with a particular focus on …

Recent developments in Aspergillus fumigatus research: diversity, drugs, and disease

N Kordana, A Johnson, K Quinn, JJ Obar… - Microbiology and …, 2025 - journals.asm.org
Advances in modern medical therapies for many previously intractable human diseases
have improved patient outcomes. However, successful disease treatment outcomes are …