Inhibition of FGF‐FGFR and VEGF‐VEGFR signalling in cancer treatment
G Liu, T Chen, Z Ding, Y Wang, Y Wei, X Wei - Cell proliferation, 2021 - Wiley Online Library
The sites of targeted therapy are limited and need to be expanded. The FGF‐FGFR
signalling plays pivotal roles in the oncogenic process, and FGF/FGFR inhibitors are a …
signalling plays pivotal roles in the oncogenic process, and FGF/FGFR inhibitors are a …
Molecular hybrids: A five-year survey on structures of multiple targeted hybrids of protein kinase inhibitors for cancer therapy
Protein kinases have grown over the past few years as a crucial target for different cancer
types. With the multifactorial nature of cancer, and the fast development of drug resistance …
types. With the multifactorial nature of cancer, and the fast development of drug resistance …
Fibroblast growth factor receptors (FGFRs) and noncanonical partners in cancer signaling
Increasing evidence indicates that success of targeted therapies in the treatment of cancer is
context-dependent and is influenced by a complex crosstalk between signaling pathways …
context-dependent and is influenced by a complex crosstalk between signaling pathways …
Research progress on the PI3K/AKT signaling pathway in gynecological cancer
X Shi, J Wang, Y Lei, C Cong… - Molecular medicine …, 2019 - spandidos-publications.com
Abstract The phosphatidylinositol 3‑kinase (PI3K)/protein kinase B (AKT) signaling pathway
is involved in the regulation of multiple cellular physiological processes by activating …
is involved in the regulation of multiple cellular physiological processes by activating …
Silencing of hsa_circ_0009035 suppresses cervical cancer progression and enhances radiosensitivity through microRNA 889-3p-dependent regulation of HOXB7
X Zhao, W Dong, G Luo, J **e, J Liu… - Molecular and Cellular …, 2021 - Taylor & Francis
Circular RNAs (circRNAs), a novel type of endogenous noncoding RNAs, have been
identified as critical regulators in human carcinogenesis. Here, we investigated the precise …
identified as critical regulators in human carcinogenesis. Here, we investigated the precise …
Design, synthesis, and anticancer evaluation of novel quinoline derivatives of ursolic acid with hydrazide, oxadiazole, and thiadiazole moieties as potent MEK …
XY **, H Chen, DD Li, AL Li, WY Wang… - Journal of enzyme …, 2019 - Taylor & Francis
In this article, a series of novel quinoline derivatives of ursolic acid (UA) bearing hydrazide,
oxadiazole, or thiadiazole moieties were designed, synthesised, and screened for their in …
oxadiazole, or thiadiazole moieties were designed, synthesised, and screened for their in …
Genomic landscapes of EBV-associated nasopharyngeal carcinoma vs. HPV-associated head and neck cancer
Epstein-Barr virus-positive nasopharyngeal carcinoma (EBV (+) NPC), and human
papillomavirus-positive head and neck squamous cell carcinoma (HPV (+) HNSCC) are two …
papillomavirus-positive head and neck squamous cell carcinoma (HPV (+) HNSCC) are two …
Targeted therapy with PI3K and FGFR inhibitors on human papillomavirus positive and negative tonsillar and base of tongue cancer lines with and without …
Objectives Human papillomavirus positive (HPV+) tonsillar and base of tongue squamous
cell carcinoma (TSCC/BOTSCC), the major subsites of oropharyngeal squamous cell …
cell carcinoma (TSCC/BOTSCC), the major subsites of oropharyngeal squamous cell …
XCL1 expression correlates with CD8-positive T cells infiltration and PD-L1 expression in squamous cell carcinoma arising from mature cystic teratoma of the ovary
Molecular characteristics of carcinoma arising from mature cystic teratoma of the ovary
(MCT) remain unclear due to its rarity. We analyzed RNA-sequencing data of 2322 pan …
(MCT) remain unclear due to its rarity. We analyzed RNA-sequencing data of 2322 pan …
Targeting fibroblast growth factor receptor (FGFR) and phosphoinositide 3-kinase (PI3K) signaling pathways in medulloblastoma cell lines
S Holzhauser, M Lukoseviciute, T Andonova… - Anticancer …, 2020 - ar.iiarjournals.org
Background/Aim: Medulloblastoma (MB) accounts for~ 20% of pediatric malignant central
nervous system tumors. Treatment strategies, including surgery, radiation therapy and/or …
nervous system tumors. Treatment strategies, including surgery, radiation therapy and/or …