Assessments of population genetic structure have become an increasing focus as they can
provide valuable insight into patterns of migration and gene flow. structure, the most highly …

Although genetic association studies have been with us for many years, even for the
simplest analyses there is little consensus on the most appropriate statistical procedures …

The identification of the genetic structure of populations from multilocus genotype data has
become a central component of modern population‐genetic data analysis. Application of …

Lighter variations of pigmentation in humans are associated with diminished number, size,
and density of melanosomes, the pigmented organelles of melanocytes. Here we show that …

Osteoporosis is a common disease with a strong genetic component characterized by
reduced bone mass, defects in the microarchitecture of bone tissue, and an increased risk of …

To fully understand the allelic variation that underlies common diseases, complete genome
sequencing for many individuals with and without disease is required. This is still not …

Large-scale association studies hold substantial promise for unraveling the genetic basis of
common human diseases. A well-known problem with such studies is the presence of …

Population stratification refers to differences in allele frequencies between cases and
controls due to systematic differences in ancestry rather than association of genes with …

Inference of individual ancestry is useful in various applications, such as admixture map**
and structured-association map**. Using information-theoretic principles, we introduce a …

We review the problem of confounding in genetic association studies, which arises
principally because of population structure and cryptic relatedness. Many treatments of the …