Angiotensin II signal transduction: an update on mechanisms of physiology and pathophysiology
The renin-angiotensin-aldosterone system plays crucial roles in cardiovascular physiology
and pathophysiology. However, many of the signaling mechanisms have been unclear. The …
and pathophysiology. However, many of the signaling mechanisms have been unclear. The …
Molecular signatures of G-protein-coupled receptors
G-protein-coupled receptors (GPCRs) are physiologically important membrane proteins that
sense signalling molecules such as hormones and neurotransmitters, and are the targets of …
sense signalling molecules such as hormones and neurotransmitters, and are the targets of …
Crystal structure of the β2 adrenergic receptor–Gs protein complex
G protein-coupled receptors (GPCRs) are responsible for the majority of cellular responses
to hormones and neurotransmitters as well as the senses of sight, olfaction and taste. The …
to hormones and neurotransmitters as well as the senses of sight, olfaction and taste. The …
High-Resolution Crystal Structure of an Engineered Human β2-Adrenergic G Protein–Coupled Receptor
Heterotrimeric guanine nucleotide–binding protein (G protein)–coupled receptors constitute
the largest family of eukaryotic signal transduction proteins that communicate across the …
the largest family of eukaryotic signal transduction proteins that communicate across the …
Structure of a nanobody-stabilized active state of the β2 adrenoceptor
SGF Rasmussen, HJ Choi, JJ Fung, E Pardon… - Nature, 2011 - nature.com
G protein coupled receptors (GPCRs) exhibit a spectrum of functional behaviours in
response to natural and synthetic ligands. Recent crystal structures provide insights into …
response to natural and synthetic ligands. Recent crystal structures provide insights into …
Structural insights into µ-opioid receptor activation
Activation of the μ-opioid receptor (μOR) is responsible for the efficacy of the most effective
analgesics. To shed light on the structural basis for μOR activation, here we report a 2.1 Å X …
analgesics. To shed light on the structural basis for μOR activation, here we report a 2.1 Å X …
Crystal structure of the human β2 adrenergic G-protein-coupled receptor
SGF Rasmussen, HJ Choi, DM Rosenbaum… - Nature, 2007 - nature.com
Structural analysis of G-protein-coupled receptors (GPCRs) for hormones and
neurotransmitters has been hindered by their low natural abundance, inherent structural …
neurotransmitters has been hindered by their low natural abundance, inherent structural …
Impact of GPCR structures on drug discovery
Structures of 70 unique G protein-coupled receptors (GPCRs) have been determined, with
over 370 structures in total bound to different ligands and the receptors in various …
over 370 structures in total bound to different ligands and the receptors in various …
Activation and allosteric modulation of a muscarinic acetylcholine receptor
Despite recent advances in crystallography and the availability of G-protein-coupled
receptor (GPCR) structures, little is known about the mechanism of their activation process …
receptor (GPCR) structures, little is known about the mechanism of their activation process …
Adenosine receptors as drug targets—what are the challenges?
Adenosine signalling has long been a target for drug development, with adenosine itself or
its derivatives being used clinically since the 1940s. In addition, methylxanthines such as …
its derivatives being used clinically since the 1940s. In addition, methylxanthines such as …