The many faces of α-synuclein: from structure and toxicity to therapeutic target

HA Lashuel, CR Overk, A Oueslati… - Nature Reviews …, 2013 - nature.com
Disorders characterized by α-synuclein (α-syn) accumulation, Lewy body formation and
parkinsonism (and in some cases dementia) are collectively known as Lewy body diseases …

α-Synuclein in Parkinson's disease

L Stefanis - Cold Spring Harbor perspectives in …, 2012 - perspectivesinmedicine.cshlp.org
α-Synuclein is a presynaptic neuronal protein that is linked genetically and
neuropathologically to Parkinson's disease (PD). α-Synuclein may contribute to PD …

The process of Lewy body formation, rather than simply α-synuclein fibrillization, is one of the major drivers of neurodegeneration

AL Mahul-Mellier, J Burtscher… - Proceedings of the …, 2020 - National Acad Sciences
Parkinson's disease (PD) is characterized by the accumulation of misfolded and aggregated
α-synuclein (α-syn) into intraneuronal inclusions named Lewy bodies (LBs). Although it is …

α-Synuclein phosphorylation at serine 129 occurs after initial protein deposition and inhibits seeded fibril formation and toxicity

SS Ghanem, NK Majbour, NN Vaikath… - Proceedings of the …, 2022 - National Acad Sciences
α-Synuclein (α-syn) phosphorylation at serine 129 (pS129–α-syn) is substantially increased
in Lewy body disease, such as Parkinson's disease (PD) and dementia with Lewy bodies …

[HTML][HTML] The function of α-synuclein

JT Bendor, TP Logan, RH Edwards - Neuron, 2013 - cell.com
Human genetics has indicated a causal role for the protein α-synuclein in the pathogenesis
of familial Parkinson's disease (PD), and the aggregation of synuclein in essentially all …

Alpha-synuclein structure and Parkinson's disease–lessons and emerging principles

RM Meade, DP Fairlie, JM Mason - Molecular neurodegeneration, 2019 - Springer
Alpha-synuclein (αS) is the major constituent of Lewy bodies and a pathogenic hallmark of
all synucleinopathathies, including Parkinson's disease (PD), dementia with Lewy bodies …

Alpha-synuclein research: defining strategic moves in the battle against Parkinson's disease

LMA Oliveira, T Gasser, R Edwards… - npj Parkinson's …, 2021 - nature.com
With the advent of the genetic era in Parkinson's disease (PD) research in 1997, α-synuclein
was identified as an important player in a complex neurodegenerative disease that affects> …

[HTML][HTML] α-Synuclein misfolding and Parkinson's disease

L Breydo, JW Wu, VN Uversky - … et Biophysica Acta (BBA)-Molecular Basis …, 2012 - Elsevier
Substantial evidence links α-synuclein, a small highly conserved presynaptic protein with
unknown function, to both familial and sporadic Parkinson's disease (PD). α-Synuclein has …

Reverse engineering Lewy bodies: how far have we come and how far can we go?

MB Fares, S Jagannath, HA Lashuel - Nature Reviews Neuroscience, 2021 - nature.com
Lewy bodies (LBs) are α-synuclein (α-syn)-rich intracellular inclusions that are an important
pathological hallmark of Parkinson disease and several other neurodegenerative diseases …

What genetics tells us about the causes and mechanisms of Parkinson's disease

O Corti, S Lesage, A Brice - Physiological reviews, 2011 - journals.physiology.org
Parkinson's disease (PD) is a common motor disorder of mysterious etiology. It is due to the
progressive degeneration of the dopaminergic neurons of the substantia nigra and is …