Review of Geant4-DNA applications for micro and nanoscale simulations

S Incerti, M Douglass, S Penfold, S Guatelli, E Bezak - Physica Medica, 2016 - Elsevier
Emerging radiotherapy treatments including targeted particle therapy, hadron therapy or
radiosensitisation of cells by high-Z nanoparticles demand the theoretical determination of …

AOP report: Development of an adverse outcome pathway for deposition of energy leading to cataracts

E Carrothers, M Appleby, V Lai… - Environmental and …, 2024 - Wiley Online Library
Cataracts are one of the leading causes of blindness, with an estimated 95 million people
affected worldwide. A hallmark of cataract development is lens opacification, typically …

Monte Carlo investigation of the increased radiation deposition due to gold nanoparticles using kilovoltage and megavoltage photons in a 3D randomized cell model

M Douglass, E Bezak, S Penfold - Medical physics, 2013 - Wiley Online Library
Purpose: Investigation of increased radiation dose deposition due to gold nanoparticles
(GNPs) using a 3D computational cell model during x‐ray radiotherapy. Methods: Two GNP …

Nanoscale radiation transport and clinical beam modeling for gold nanoparticle dose enhanced radiotherapy (GNPT) using X-rays

P Zygmanski, E Sajo - The British journal of radiology, 2016 - academic.oup.com
We review radiation transport and clinical beam modelling for gold nanoparticle dose-
enhanced radiotherapy using X-rays. We focus on the nanoscale radiation transport and its …

Future development of biologically relevant dosimetry

H Palmans, H Rabus, AL Belchior… - The British journal of …, 2015 - academic.oup.com
Proton and ion beams are radiotherapy modalities of increasing importance and interest.
Because of the different biological dose response of these radiations as compared with high …

Geometrical structures for radiation biology research as implemented in the TOPAS-nBio toolkit

AL McNamara, J Ramos-Méndez, J Perl… - Physics in Medicine …, 2018 - iopscience.iop.org
Computational simulations, such as Monte Carlo track structure simulations, offer a powerful
tool for quantitatively investigating radiation interactions within cells. The modelling of the …

[HTML][HTML] Intercomparison of Monte Carlo calculated dose enhancement ratios for gold nanoparticles irradiated by X-rays: Assessing the uncertainty and correct …

H Rabus, WB Li, C Villagrasa, J Schuemann… - Physica Medica, 2021 - Elsevier
Abstract Results of a Monte Carlo code intercomparison exercise for simulations of the dose
enhancement from a gold nanoparticle (GNP) irradiated by X-rays have been recently …

Computed tomography imaging-guided radiotherapy by targeting upconversion nanocubes with significant imaging and radiosensitization enhancements

H **ng, X Zheng, Q Ren, W Bu, W Ge, Q **ao… - Scientific reports, 2013 - nature.com
The clinical potentials of radiotherapy could not be achieved completely because of the
inaccurate positioning and inherent radioresistance of tumours. In this study, a novel active …

AOP report: Development of an adverse outcome pathway for deposition of energy leading to learning and memory impairment

A Sleiman, KB Miller, D Flores, J Kuan… - Environmental and …, 2024 - Wiley Online Library
Understanding radiation‐induced non‐cancer effects on the central nervous system (CNS)
is essential for the risk assessment of medical (eg, radiotherapy) and occupational (eg …

AOP Report: Development of an adverse outcome pathway for deposition of energy leading to bone loss

S Sandhu, M Keyworth, S Karimi‐Jashni… - Environmental and …, 2024 - Wiley Online Library
Bone loss, commonly seen in osteoporosis, is a condition that entails a progressive decline
of bone mineral density and microarchitecture, often seen in post‐menopausal women …