Causes and consequences of snake venom variation

NR Casewell, TNW Jackson, AH Laustsen… - Trends in …, 2020 - cell.com
Snake venoms are mixtures of toxins that vary extensively between and within snake
species. This variability has serious consequences for the management of the world's 1.8 …

Multifunctional toxins in snake venoms and therapeutic implications: from pain to hemorrhage and necrosis

CR Ferraz, A Arrahman, C **e, NR Casewell… - Frontiers in ecology …, 2019 - frontiersin.org
Animal venoms have evolved over millions of years for prey capture and defense from
predators and rivals. Snake venoms, in particular, have evolved a wide diversity of peptides …

Synthetic development of a broadly neutralizing antibody against snake venom long-chain α-neurotoxins

IS Khalek, RR Senji Laxme, YTK Nguyen… - Science Translational …, 2024 - science.org
Snakebite envenoming is a major global public health concern for which improved therapies
are urgently needed. The antigenic diversity present in snake venom toxins from various …

The biology and evolution of spider venoms

T Lüddecke, V Herzig, BM Von Reumont… - Biological …, 2022 - Wiley Online Library
Spiders are diverse, predatory arthropods that have inhabited Earth for around 400 million
years. They are well known for their complex venom systems that are used to overpower …

[HTML][HTML] Beyond the 'big four': Venom profiling of the medically important yet neglected Indian snakes reveals disturbing antivenom deficiencies

RRS Laxme, S Khochare, HF de Souza… - PLoS neglected …, 2019 - journals.plos.org
Background Snakebite in India causes the highest annual rates of death (46,000) and
disability (140,000) than any other country. Antivenom is the mainstay treatment of …

Snake venom peptides: Tools of biodiscovery

A Munawar, SA Ali, A Akrem, C Betzel - Toxins, 2018 - mdpi.com
Nature endowed snakes with a lethal secretion known as venom, which has been fine-tuned
over millions of years of evolution. Snakes utilize venom to subdue their prey and to survive …

Biogeographical venom variation in the Indian spectacled cobra (Naja naja) underscores the pressing need for pan-India efficacious snakebite therapy

RR Senji Laxme, S Attarde, S Khochare… - PLOS neglected …, 2021 - journals.plos.org
Background Snake venom composition is dictated by various ecological and environmental
factors, and can exhibit dramatic variation across geographically disparate populations of …

The rise and fall of an evolutionary innovation: contrasting strategies of venom evolution in ancient and young animals

K Sunagar, Y Moran - PLoS genetics, 2015 - journals.plos.org
Animal venoms are theorized to evolve under the significant influence of positive Darwinian
selection in a chemical arms race scenario, where the evolution of venom resistance in prey …

[HTML][HTML] Snakebite: When the human touch becomes a bad touch

BG Fry - Toxins, 2018 - mdpi.com
Many issues and complications in treating snakebite are a result of poor human social,
economic and clinical intervention and management. As such, there is scope for significant …

[HTML][HTML] Sea anemone toxins: A structural overview

B Madio, GF King, EAB Undheim - Marine drugs, 2019 - mdpi.com
Sea anemones produce venoms of exceptional molecular diversity, with at least 17 different
molecular scaffolds reported to date. These venom components have traditionally been …