Animal models of depression: what can they teach us about the human disease?
Depression is apparently the most common psychiatric disease among the mood disorders
affecting about 10% of the adult population. The etiology and pathogenesis of depression …
affecting about 10% of the adult population. The etiology and pathogenesis of depression …
Pyridine alkaloids with activity in the central nervous system
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Strategies for the treatment of Parkinson's disease: beyond dopamine
Parkinson's disease (PD) is the second-leading cause of dementia and is characterized by a
progressive loss of dopaminergic neurons in the substantia nigra alongside the presence of …
progressive loss of dopaminergic neurons in the substantia nigra alongside the presence of …
Cotinine: pharmacologically active metabolite of nicotine and neural mechanisms for its actions
X Tan, K Vrana, ZM Ding - Frontiers in Behavioral Neuroscience, 2021 - frontiersin.org
Tobacco use disorder continues to be a leading public health issue and cause of premature
death in the United States. Nicotine is considered as the major tobacco alkaloid causing …
death in the United States. Nicotine is considered as the major tobacco alkaloid causing …
[HTML][HTML] Beneficial effects of nicotine, cotinine and its metabolites as potential agents for Parkinson's disease
Parkinson's disease (PD) is a progressive neurodegenerative disorder, which is
characterized by neuroinflammation, dopaminergic neuronal cell death and motor …
characterized by neuroinflammation, dopaminergic neuronal cell death and motor …
S-equol, a metabolite of dietary soy isoflavones, alleviates lipopolysaccharide-induced depressive-like behavior in mice by inhibiting neuroinflammation and …
C Lu, R Gao, Y Zhang, N Jiang, Y Chen, J Sun… - Food & Function, 2021 - pubs.rsc.org
Systemic injection with lipopolysaccharide can lead to depressive-like behavior in
experimental animals by inducing neuroinflammation and is considered to be a classic …
experimental animals by inducing neuroinflammation and is considered to be a classic …
Repeated daily restraint stress induces adaptive behavioural changes in both adult and juvenile mice
AM Sadler, SJ Bailey - Physiology & behavior, 2016 - Elsevier
Chronic stress is known to be a risk factor for the development of depression and anxiety,
disorders which often begin during adolescence. Restraint stress is a commonly used …
disorders which often begin during adolescence. Restraint stress is a commonly used …
Differential effects of stress exposure via two types of restraint apparatuses on behavior and plasma corticosterone level in inbred male BALB/cAJcl mice
Aims Restraint stress is one of the most widely used experimental methods for generating
rodent models of stress‐induced neuropsychiatric disorders, such as depression and …
rodent models of stress‐induced neuropsychiatric disorders, such as depression and …
Alpha-7 nicotinic receptor allosteric modulator PNU120596 prevents lipopolysaccharide-induced anxiety, cognitive deficit and depression-like behaviors in mice
Neuroinflammation is often associated with the development of major depressive disorder
(MDD)-related symptoms. Previous studies have indicated that activation of glial cells …
(MDD)-related symptoms. Previous studies have indicated that activation of glial cells …
Developmental impaired Akt signaling in the Shank1 and Shank3 double knock-out mice
Human mutations and haploinsufficiency of the SHANK family genes are associated with
autism spectrum disorders (ASD) and intellectual disability (ID). Complex phenotypes have …
autism spectrum disorders (ASD) and intellectual disability (ID). Complex phenotypes have …