White matter hyperintensities (WMH) are the most common brain-imaging feature of cerebral
small vessel disease (SVD), hypertension being the main known risk factor. Here, we …

Background Identification of white matter microstructure differences and similarities between
major depression and bipolar disorder is a necessary step to better understand the …

Statistical genetic models of genotype-by-environment (G× E) interaction can be divided into
two general classes, one on G× E interaction in response to dichotomous environments (eg …

Imaging genomics is a new field of investigation that seeks to gain insights into the impact of
human genetic variation on the structure, chemistry, and function of neural systems in health …

The degree to which genetic factors influence brain connectivity is beginning to be
understood. Large-scale efforts are underway to map the profile of genetic effects in various …

Importance Efforts to remediate the multiple cognitive function impairments in schizophrenia
should consider white matter as one of the underlying neural mechanisms. Objective To …

Mutations in genes encoding proteins that are involved in mitochondrial heme synthesis,
iron-sulfur cluster biogenesis, and mitochondrial protein synthesis have previously been …

Cognitive deficits contribute to functional disability in patients with schizophrenia and may
be related to altered functional networks that serve cognition. We evaluated the integrity of …

Schizophrenia (SZ) is a severe psychiatric illness associated with an elevated risk for
develo** Alzheimer's disease (AD). Both SZ and AD have white matter abnormalities and …

The neurodevelopmental model of schizophrenia is supported by multi-level impairments
shared among schizophrenia and neurodevelopmental disorders. Despite schizophrenia …