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An overview of drug discovery and development
A new medicine will take an average of 10–15 years and more than US $2 billion before it
can reach the pharmacy shelf. Traditionally, drug discovery relied on natural products as the …
can reach the pharmacy shelf. Traditionally, drug discovery relied on natural products as the …
Chemotherapy of leishmaniasis: present challenges
Cutaneous and visceral leishmaniasis are amongst the most devastating infectious diseases
of our time, affecting millions of people worldwide. The treatment of these serious diseases …
of our time, affecting millions of people worldwide. The treatment of these serious diseases …
Creating and screening natural product libraries
Covering: up to 2020 The National Cancer Institute of the United States (NCI) has initiated a
Cancer Moonshot program entitled the NCI Program for Natural Product Discovery. As part …
Cancer Moonshot program entitled the NCI Program for Natural Product Discovery. As part …
[HTML][HTML] Future directions for the discovery of natural product-derived immunomodulating drugs: an IUPHAR positional review
Drug discovery from natural sources is going through a renaissance, having spent many
decades in the shadow of synthetic molecule drug discovery, despite the fact that natural …
decades in the shadow of synthetic molecule drug discovery, despite the fact that natural …
Current drug therapy and pharmaceutical challenges for Chagas disease
One of the most significant health problems in the American continent in terms of human
health, and socioeconomic impact is Chagas disease, caused by the protozoan parasite …
health, and socioeconomic impact is Chagas disease, caused by the protozoan parasite …
Leishmaniasis drug discovery: recent progress and challenges in assay development
Highlights•Leishmaniasis remains a neglected tropical disease, with a high unmet medical
need.•Therapeutic efficacy varies depending on the species of Leishmania parasite.•Leads …
need.•Therapeutic efficacy varies depending on the species of Leishmania parasite.•Leads …
Innovation in neglected tropical disease drug discovery and development
Background: Neglected tropical diseases (NTDs) are closely related to poverty and affect
over a billion people in develo** countries. The unmet treatment needs cause high …
over a billion people in develo** countries. The unmet treatment needs cause high …
[HTML][HTML] Current screening methodologies in drug discovery for selected human diseases
The increase of many deadly diseases like infections by multidrug-resistant bacteria implies
re-inventing the wheel on drug discovery. A better comprehension of the metabolisms and …
re-inventing the wheel on drug discovery. A better comprehension of the metabolisms and …
Navigating drug repurposing for Chagas disease: Advances, challenges, and opportunities
Chagas disease is a vector-borne illness caused by the protozoan parasite Trypanosoma
cruzi (T. cruzi). It poses a significant public health burden, particularly in the poorest regions …
cruzi (T. cruzi). It poses a significant public health burden, particularly in the poorest regions …
[HTML][HTML] Challenges in drug discovery targeting TriTryp diseases with an emphasis on leishmaniasis
Tritryps diseases are devastating parasitic neglected infections caused by Leishmania spp.,
Trypanosoma cruzi and Trypanosoma brucei subspecies. Together, these parasites affect …
Trypanosoma cruzi and Trypanosoma brucei subspecies. Together, these parasites affect …