Oxidative stress (OS) and inflammation are two important and well-studied pathological
hallmarks of neurodegenerative diseases (NDDs). Due to elevated oxygen consumption, the …

Excitotoxicity is a phenomenon that describes the toxic actions of excitatory
neurotransmitters, primarily glutamate, where the exacerbated or prolonged activation of …

Directing the differentiation of induced pluripotent stem cells into motor neurons has allowed
investigators to develop new models of amyotrophic lateral sclerosis (ALS). However …

Amyotrophic lateral sclerosis (ALS) is an adult onset neurodegenerative disease that results
in motor dysfunction and death, generally from respiratory failure. 90% of ALS cases are …

Brain derived neurotrophic factor (BDNF) is well recognized for its neuroprotective functions,
via activation of its high affinity receptor, tropomysin related kinase B (TrkB). In addition …

Damage to DNA is generally considered to be a harmful process associated with aging and
aging-related disorders such as neurodegenerative diseases that involve the selective …

Mutations in the FUS gene cause amyotrophic lateral sclerosis (ALS-FUS). Mutant FUS is
known to confer cytoplasmic gain of function but its effects in the nucleus are less …

Synapse loss is an early feature shared by many neurodegenerative diseases, and it
represents the major correlate of cognitive impairment. Recent studies reveal that microglia …

Amyotrophic lateral sclerosis (ALS) is the most common motor neuron (MN) disease in
adults with no curative treatment. Neurofilament (NF) level in patient'fluids have recently …

The onset of amyotrophic lateral sclerosis (ALS) is conventionally considered as
commencing with the recognition of clinical symptoms. We propose that, in common with …