Alzheimer's disease (AD) is a neurodegenerative disease characterized by progressive
memory loss along with neuropsychiatric symptoms and a decline in activities of daily life. Its …

Pyruvate is a keystone molecule critical for numerous aspects of eukaryotic and human
metabolism. Pyruvate is the end-product of glycolysis, is derived from additional sources in …

Mitochondrial dysfunction and low nicotinamide adenine dinucleotide (NAD+) levels are
hallmarks of skeletal muscle ageing and sarcopenia,–, but it is unclear whether these …

Nicotinamide adenine dinucleotide (NAD+) is a co-substrate for several enzymes, including
the sirtuin family of NAD+-dependent protein deacylases. Beneficial effects of increased …

The biological effects of urolithins remain poorly characterized, despite wide-spread human
exposure via the dietary consumption of their metabolic precursors, the ellagitannins, which …

NAD+ is an important cofactor regulating metabolic homeostasis and a rate-limiting
substrate for sirtuin deacylases. We show that NAD+ levels are reduced in aged mice and …

Longevity is regulated by a network of closely linked metabolic systems. We used a
combination of mouse population genetics and RNA interference in Caenorhabditis elegans …

Acetyl-CoA is a metabolite at the crossroads of central metabolism and the substrate of
histone acetyltransferases regulating gene expression. In many tissues fasting or lifespan …

The SLC16 gene family has fourteen members. Four (SLC16A1, SLC16A3, SLC16A7, and
SLC16A8) encode monocarboxylate transporters (MCT1, MCT4, MCT2, and MCT3 …

DNA variants that modulate life span provide insight into determinants of health, disease,
and aging. Through analyses in the UM-HET3 mice of the Interventions Testing Program …