Signaling pathways and targeted therapies for psoriasis

J Guo, H Zhang, W Lin, L Lu, J Su… - Signal transduction and …, 2023‏ - nature.com
Psoriasis is a common, chronic, and inflammatory skin disease with a high burden on
individuals, health systems, and society worldwide. With the immunological pathologies and …

Pathophysiology, clinical presentation, and treatment of psoriasis: a review

AW Armstrong, C Read - Jama, 2020‏ - jamanetwork.com
Importance Approximately 125 million people worldwide have psoriasis. Patients with
psoriasis experience substantial morbidity and increased rates of inflammatory arthritis …

The role of helper T cells in psoriasis

P Hu, M Wang, H Gao, A Zheng, J Li, D Mu… - Frontiers in …, 2021‏ - frontiersin.org
Psoriasis is a complex, chronic relapsing and inflammatory skin disorder with a prevalence
of approximately 2% in the general population worldwide. Psoriasis can be triggered by …

Joint AAD-NPF guidelines of care for the management and treatment of psoriasis with biologics

A Menter, BE Strober, DH Kaplan, D Kivelevitch… - Journal of the American …, 2019‏ - Elsevier
Psoriasis is a chronic, inflammatory multisystem disease that affects up to 3.2% of the US
population. This guideline addresses important clinical questions that arise in psoriasis …

Systemic pharmacological treatments for chronic plaque psoriasis: a network meta‐analysis

E Sbidian, A Chaimani, R Guelimi… - Cochrane Database …, 2023‏ - cochranelibrary.com
Background Psoriasis is an immune‐mediated disease with either skin or joints
manifestations, or both, and it has a major impact on quality of life. Although there is …

Discovery of the IL-23/IL-17 signaling pathway and the treatment of psoriasis

JE Hawkes, BY Yan, TC Chan… - The Journal of …, 2018‏ - journals.aai.org
Psoriasis vulgaris is a common, heterogeneous, chronic inflammatory skin disease
characterized by thickened, red, scaly plaques and systemic inflammation. Psoriasis is also …

Prevalence of psoriatic arthritis in patients with psoriasis: a systematic review and meta-analysis of observational and clinical studies

F Alinaghi, M Calov, LE Kristensen… - Journal of the American …, 2019‏ - Elsevier
Background Wide-ranging prevalence estimates of psoriatic arthritis (PsA) in patients with
psoriasis have been reported. Objectives To assess the prevalence and incidence of PsA in …

Joint AAD-NPF guidelines of care for the management and treatment of psoriasis with awareness and attention to comorbidities

CA Elmets, CL Leonardi, DMR Davis… - Journal of the American …, 2019‏ - Elsevier
Psoriasis is a chronic, inflammatory, multisystem disease that affects up to 3.2% of the US
population. This guideline addresses important clinical questions that arise in psoriasis …

[HTML][HTML] Efficacy and safety of guselkumab, an anti-interleukin-23 monoclonal antibody, compared with adalimumab for the continuous treatment of patients with …

A Blauvelt, KA Papp, CEM Griffiths, B Randazzo… - Journal of the american …, 2017‏ - Elsevier
Background Guselkumab, an interleukin-23 blocker, was superior to adalimumab in treating
moderate to severe psoriasis in a phase II trial. Objectives We sought to compare efficacy …

Current developments in the immunology of psoriasis

F Grän, A Kerstan, E Serfling… - The Yale journal of …, 2020‏ - pmc.ncbi.nlm.nih.gov
Psoriasis is a frequent inflammatory skin disease. Fundamental research on the
pathogenesis of psoriasis has substantially increased our understanding of skin …