Pharmapolymers in the 21st century: Synthetic polymers in drug delivery applications
The administration of drugs, as a main challenge of pharmaceutical and medicinal
applications, has certainly benefited from the application of synthetic polymers. However …
applications, has certainly benefited from the application of synthetic polymers. However …
Supercritical fluid technology: an emphasis on drug delivery and related biomedical applications
During the past few decades, supercritical fluid (SCF) has emerged as an effective
alternative for many traditional pharmaceutical manufacturing processes. Operating active …
alternative for many traditional pharmaceutical manufacturing processes. Operating active …
Franz diffusion cell approach for pre-formulation characterisation of ketoprofen semi-solid dosage forms
This study aimed to evaluate and compare, using the methodology of Franz diffusion cells,
the ketoprofen (KTP) releasing profiles of two formulations: A gel and a conventional …
the ketoprofen (KTP) releasing profiles of two formulations: A gel and a conventional …
The nutraceutical bioavailability classification scheme: classifying nutraceuticals according to factors limiting their oral bioavailability
The oral bioavailability of a health-promoting dietary component (nutraceutical) may be
limited by various physicochemical and physiological phenomena: liberation from food …
limited by various physicochemical and physiological phenomena: liberation from food …
Cyclodextrin‐based formulations: a non‐invasive platform for targeted drug delivery
C Muankaew, T Loftsson - Basic & clinical pharmacology & …, 2018 - Wiley Online Library
Cyclodextrins (CD s) are recognized as promising pharmaceutical excipients due to their
unique ability to form water‐soluble inclusion complexes with various poorly soluble …
unique ability to form water‐soluble inclusion complexes with various poorly soluble …
Exploiting the phenomenon of liquid–liquid phase separation for enhanced and sustained membrane transport of a poorly water-soluble drug
Recent studies on aqueous supersaturated lipophilic drug solutions prepared by methods
including antisolvent addition, pH swing, or dissolution of amorphous solid dispersions …
including antisolvent addition, pH swing, or dissolution of amorphous solid dispersions …
Targeted protein degradation: advances, challenges, and prospects for computational methods
The therapeutic approach of targeted protein degradation (TPD) is gaining momentum due
to its potentially superior effects compared with protein inhibition. Recent advancements in …
to its potentially superior effects compared with protein inhibition. Recent advancements in …
A win–win solution in oral delivery of lipophilic drugs: supersaturation via amorphous solid dispersions increases apparent solubility without sacrifice of intestinal …
JM Miller, A Beig, RA Carr, JK Spence… - Molecular …, 2012 - ACS Publications
Recently, we have revealed a trade-off between solubility increase and permeability
decrease when solubility-enabling oral formulations are employed. We have shown this …
decrease when solubility-enabling oral formulations are employed. We have shown this …
Formulation of a danazol cocrystal with controlled supersaturation plays an essential role in improving bioavailability
SL Childs, P Kandi, SR Lingireddy - Molecular pharmaceutics, 2013 - ACS Publications
Cocrystals have become an established and adopted approach for creating crystalline
solids with improved physical properties, but incorporating cocrystals into enabling pre …
solids with improved physical properties, but incorporating cocrystals into enabling pre …
The solubility–permeability interplay and oral drug formulation design: Two heads are better than one
Poor aqueous solubility is a major challenge in today's biopharmaceutics. While solubility-
enabling formulations can significantly increase the apparent solubility of the drug, the …
enabling formulations can significantly increase the apparent solubility of the drug, the …