Progression in translational research on spinal cord injury based on microenvironment imbalance

B Fan, Z Wei, S Feng - Bone research, 2022 - nature.com
Spinal cord injury (SCI) leads to loss of motor and sensory function below the injury level
and imposes a considerable burden on patients, families, and society. Repair of the injured …

Recent progress and challenges in the treatment of spinal cord injury

T Tian, S Zhang, M Yang - Protein & cell, 2023 - academic.oup.com
Spinal cord injury (SCI) disrupts the structural and functional connectivity between the higher
center and the spinal cord, resulting in severe motor, sensory, and autonomic dysfunction …

[HTML][HTML] Walking naturally after spinal cord injury using a brain–spine interface

H Lorach, A Galvez, V Spagnolo, F Martel, S Karakas… - Nature, 2023 - nature.com
A spinal cord injury interrupts the communication between the brain and the region of the
spinal cord that produces walking, leading to paralysis 1, 2. Here, we restored this …

Activity-dependent spinal cord neuromodulation rapidly restores trunk and leg motor functions after complete paralysis

A Rowald, S Komi, R Demesmaeker, E Baaklini… - Nature medicine, 2022 - nature.com
Epidural electrical stimulation (EES) targeting the dorsal roots of lumbosacral segments
restores walking in people with spinal cord injury (SCI). However, EES is delivered with …

Epidural stimulation of the cervical spinal cord for post-stroke upper-limb paresis

MP Powell, N Verma, E Sorensen, E Carranza… - Nature medicine, 2023 - nature.com
Cerebral strokes can disrupt descending commands from motor cortical areas to the spinal
cord, which can result in permanent motor deficits of the arm and hand. However, below the …

Multifunctional conductive and electrogenic hydrogel repaired spinal cord injury via immunoregulation and enhancement of neuronal differentiation

M Liu, W Zhang, S Han, D Zhang, X Zhou… - Advanced …, 2024 - Wiley Online Library
Spinal cord injury (SCI) is a refractory neurological disorder. Due to the complex
pathological processes, especially the secondary inflammatory cascade and the lack of …

Electrical stimulation for the treatment of spinal cord injuries: A review of the cellular and molecular mechanisms that drive functional improvements

RM Dorrian, CF Berryman, A Lauto… - Frontiers in Cellular …, 2023 - frontiersin.org
Spinal cord injury (SCI) is a devastating condition that causes severe loss of motor, sensory
and autonomic functions. Additionally, many individuals experience chronic neuropathic …

Therapeutic acute intermittent hypoxia: A translational roadmap for spinal cord injury and neuromuscular disease

AK Vose, JF Welch, J Nair, EA Dale, EJ Fox… - Experimental …, 2022 - Elsevier
We review progress towards greater mechanistic understanding and clinical translation of a
strategy to improve respiratory and non-respiratory motor function in people with …

Single-cell analysis reveals region-heterogeneous responses in rhesus monkey spinal cord with complete injury

Y Fan, X Wu, S Han, Q Zhang, Z Sun, B Chen… - Nature …, 2023 - nature.com
Spinal cord injury (SCI) leads to severe sensory and motor dysfunction below the lesion.
However, the cellular dynamic responses and heterogeneity across different regions below …

Sensory restoration by epidural stimulation of the lateral spinal cord in upper-limb amputees

S Chandrasekaran, AC Nanivadekar, G McKernan… - elife, 2020 - elifesciences.org
Restoring somatosensory feedback to people with limb amputations is crucial to improve
prosthetic control. Multiple studies have demonstrated that peripheral nerve stimulation and …